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A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms

التفاصيل البيبلوغرافية
العنوان: A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms
المؤلفون: Dahnhardt D, Erhart G, Paulweber B, Mack S, Coassin S, Strauch K, Meitinger T, Yousri NA, Khahonen M, Seppala I, Rueedi R, Hunt SC, Marques-Vidal P, Kronenberg F, Schonherr S, Peters A, Vollenweider P, Gieger C, Waeber G, Stockl A, Lamina C, Lehtimaki T, Ried JS, Bergmann S, Kedenko L, Raitakari OT, Forer L
المساهمون: sydäntutkimuskeskus, Research Centre of Applied and Preventive Cardiovascular Medicine (CAPC), tyks, vsshp, tyks, vsshp, 2607004
بيانات النشر: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Yhdysvallat (USA)
United States
US
سنة النشر: 2022
المجموعة: University of Turku: UTUPub / Turun yliopisto
الوصف: High lipoprotein (a) [Lp(a)] concentrations are an independent risk factor for cardiovascular outcomes. Concentrations are strongly influenced by apo(a) kringle IV repeat isoforms. We aimed to identify genetic loci associated with Lp(a) concentrations using data from five genome- wide association studies (n = 13,781). We identified 48 independent SNPs in the LPA and 1 SNP in the APOE gene region to be significantly associated with Lp(a) concentrations. We also adjusted for apo(a) isoforms to identify loci affecting Lp(a) levels independently from them, which resulted in 31 SNPs (30 in the LPA, 1 in the APOE gene region). Seven
نوع الوثيقة: other/unknown material
اللغة: English
تدمد: 0022-2275
العلاقة: 58; Journal of Lipid Research; 10; https://www.utupub.fi/handle/10024/164985Test; URN:NBN:fi-fe2021042717174
الإتاحة: https://www.utupub.fi/handle/10024/164985Test
رقم الانضمام: edsbas.3E0326D0
قاعدة البيانات: BASE
الوصف
تدمد:00222275