دورية أكاديمية
Spatially explicit analysis reveals complex human genetic gradients in the Iberian Peninsula
| العنوان: | Spatially explicit analysis reveals complex human genetic gradients in the Iberian Peninsula |
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| المؤلفون: | Pimenta, Joâo, Lopes, Alexandra M., Carracedo Álvarez, Ángel, Arenas Busto, Miguel, Amorim, António, Comas Amengual, Ángel |
| بيانات النشر: | Scientific Reports Bioquímica, xenética e inmunoloxía Xenómica e Biomedicina |
| سنة النشر: | 2019 |
| المجموعة: | University of Vigo: Investigo (Repositorio Institucional de la Universidade de Vigo) |
| مصطلحات موضوعية: | 2409.03 Genética de Poblaciones, 2410.07 Genética Humana, 2409 Genética |
| الوصف: | The Iberian Peninsula is a well-delimited geographic region with a rich and complex human history. However, the causes of its genetic structure and past migratory dynamics are not yet fully understood. In order to shed light on them, here we evaluated the gene flow and genetic structure throughout the Iberian Peninsula with spatially explicit modelling applied to a georeferenced genetic dataset composed of genome-wide SNPs from 746 individuals belonging to 17 different regions of the Peninsula. We found contrasting patterns of genetic structure throughout Iberia. In particular, we identified strong patterns of genetic differentiation caused by relevant barriers to gene flow in northern regions and, on the other hand, a large genetic similarity in central and southern regions. In addition, our results showed a preferential north to south migratory dynamics and suggest a sex-biased dispersal in Mediterranean and southern regions. The estimated genetic patterns did not fit with the geographical relief of the Iberian landscape and they rather seem to follow political and linguistic territorial boundaries. ; Fundação para a Ciência e a Tecnologia | Ref. POCI-01-0145-FEDER-007274 ; Fundação para a Ciência e a Tecnologia | Ref. SFRH/BD/97200/2013 ; Fundação para a Ciência e a Tecnologia | Ref. IF/01262/2014 ; Ministerio de Economía | Ref. RYC-2015-18241 ; Ministerio de Economía | Ref. MDM-2014-0370 ; Ministerio de Economía y Competitividad | Ref. CGL2016-75389-P |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 20452322 |
| العلاقة: | info:eu-repo/grantAgreement/MINECO//RYC-2015-18241/ES; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MDM-2014-0370/ES; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CGL2016-75389-P/ES; Scientific Reports, 9(1): 7825 (2019); http://hdl.handle.net/11093/4028Test; http://www.nature.com/articles/s41598-019-44121-6Test |
| DOI: | 10.1038/s41598-019-44121-6 |
| الإتاحة: | https://doi.org/10.1038/s41598-019-44121-6Test http://hdl.handle.net/11093/4028Test http://www.nature.com/articles/s41598-019-44121-6Test |
| حقوق: | Attribution 4.0 International ; https://creativecommons.org/licenses/by/4.0Test/ ; openAccess |
| رقم الانضمام: | edsbas.EFDE8001 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-019-44121-6 |