دورية أكاديمية
School Age Developmental Outcomes of Children Conceived by IVF Compared with Controls: A Population Linkage Study
| العنوان: | School Age Developmental Outcomes of Children Conceived by IVF Compared with Controls: A Population Linkage Study |
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| المؤلفون: | Amber KENNEDY, Beverley VOLLENHOVEN, Richard HISCOCK, Catharyn STERN, Susan WALKER, Jeanie CHEONG, Jon QUACH, Roxanne HASTIE, David WILKINSON, John MCBAIN, Lyle GURRIN, Vivien MACLACHLAN, Franca AGRESTA, Susan BAOHM, Stephen TONG, Anthea LINDQUIST |
| المصدر: | Fertility & Reproduction, Vol 04, Iss 03n04, Pp 137-137 (2022) |
| بيانات النشر: | World Scientific Publishing, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Reproduction |
| مصطلحات موضوعية: | Reproduction, QH471-489 |
| الوصف: | Background: There has been increasing interest in assessing longer term developmental and health outcomes in IVF-conceived offspring compared with those born after natural conception. So far, the findings have been conflicting. The Australian Early Developmental Consensus (AEDC) assesses children in their first year of primary school across five domains; physical health and wellbeing, social competence, emotional maturity, language and cognitive skills, and communication skills and general knowledge. Aim: To compare school entry (5-7 years of age) outcomes in IVF-conceived children in Victoria with naturally conceived controls. Method: We undertook a statewide data linkage study, with perinatal data (births 2005-2014) linked to data from major IVF providers in Victoria and the AEDC. Our approach to analysis included: complete case analysis, multiple imputation of missing data, consideration of clustering (siblings) and inverse probability weighted modeling to adjust for covariates. Our primary outcome was an AEDC score indicative of developmental vulnerability in two or more domains. We adjusted for the child’s age at assessment, sex, highest level of maternal education, maternal age, parity, SEIFA (Socio-Economic Indexes for Areas) quintile, language background other than English, and Aboriginal and Torres Strait Islander (ATSI) status. Results: The linked dataset comprised 163,418 children, including 4,441 IVF-conceived children. The IVF conceived population had older, more highly educated mothers who lived in more affluent areas and were less likely to be from non-English speaking backgrounds or identify as ATSI. IVF-conceived children were less likely to be developmentally vulnerable, in both unadjusted (RR 0.59, 95%CI: 0.52-0.67, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 26613182 2661-3174 2661-3182 |
| العلاقة: | https://doaj.org/toc/2661-3182Test; https://doaj.org/toc/2661-3174Test |
| DOI: | 10.1142/S2661318222740498 |
| الوصول الحر: | https://doaj.org/article/cb268cf677e64d95a6bb988bbb0b0e03Test |
| رقم الانضمام: | edsdoj.b268cf677e64d95a6bb988bbb0b0e03 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 26613182 26613174 |
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| DOI: | 10.1142/S2661318222740498 |