دورية أكاديمية
TP53 rs1042522 polymorphism and early-onset breast cancer
| العنوان: | TP53 rs1042522 polymorphism and early-onset breast cancer |
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| المؤلفون: | Icen-Taskin, Irmak, Irtegun-Kandemir, Sevgi, Munzuroglu, Omer |
| بيانات النشر: | Wolters Kluwer Medknow Publications |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Breast Neoplasms, Early Onset, Genotype, Rs1042522, Tp53 |
| الوصف: | Background: Breast cancer is the leading cause of cancer deaths among women. Early-onset breast cancer is well recognized as it clinically differs from old-age diagnosed breast neoplasms. TP53 rs1042522 polymorphism relates to the risk of breast neoplasms, but this relationship in Turkish early-onset breast cancer patients has not been investigated yet. We aimed to search the relationship between TP53 rs1042522 polymorphism and young Turkish breast cancer patients. Materials and Methods: Ninety-six female breast cancer patients who were <= 40 years of age and 96 healthy controls were enrolled in our study. Participants were genotyped by the hybridization probe system. Results: We identified that the genotype frequencies of rs1042522 were significantly different between controls and cases (P = 0.027). Participants carrying CG genotype had also reduced breast cancer risk (odds ratio = 0.4196, 95% confidence interval: 0.1941-0.9067, P = 0.027). Our results revealed that there is an association between GG and CG + CC genotype groups with progesterone receptor (PgR) status (P = 0.0219). Conclusion: Our findings indicate that the CG genotype is a protective factor against breast neoplasms. No other clinicopathologic parameters except for PgR status were found to be related to rs1042522 polymorphism in young Turkish breast cancer patients. ; Firat University Scientific Research Projects Unit [MF.16.31] ; This work has been supported by Firat University Scientific Research Projects Unit with project number MF.16.31. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1735-1995 1735-7136 |
| العلاقة: | Journal of Research in Medical Sciences; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.4103/jrms.JRMS_506_19Test; https://hdl.handle.net/11468/19565Test; 25; WOS:000613241400005; 2-s2.0-85085173243; Q3 |
| DOI: | 10.4103/jrms.JRMS_506_19 |
| الإتاحة: | https://doi.org/10.4103/jrms.JRMS_506_19Test https://hdl.handle.net/11468/19565Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7CDE53A1 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 17351995 17357136 |
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| DOI: | 10.4103/jrms.JRMS_506_19 |