دورية أكاديمية
The relationship between coronavirus disease-2019-positive patients and plasma interleukins and transforming growth factor-β levels
| العنوان: | The relationship between coronavirus disease-2019-positive patients and plasma interleukins and transforming growth factor-β levels |
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| المؤلفون: | Vatansever H., Sayan, Murat, Önal, Melike Özgül, Akhan, Sıla, Özel, Selcan, Şanlıdağ, Tamer |
| المساهمون: | MÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, orcid:0000-0001-6710-5729, Önal, Melike Özgül |
| بيانات النشر: | Wolters Kluwer Medknow Publications |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Coronavirus disease-2019, Cytokine, Enzyme-linked immunosorbent assay, Interleukin, Plasma |
| الوصف: | Objective: The aim of this study is to reveal the relationship between the cytokine plasma levels and symptoms of coronavirus disease-2019 (COVID-19)-positive patients, which is characterized by serious respiratory syndromes. Materials and Methods: Severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)-positive patients were evaluated in four groups. Group 1 patients had no symptoms. Group 2 patients were mildly symptomatic. Group 3 patients had multiple symptoms. Group 4 patients had all symptoms of acute respiratory distress syndrome. Analysis of interleukin (IL)-17A, transforming growth factor-β1 (TGF-β1), and IL-6 concentrations in plasma samples taken from patients were examined by enzyme-linked immunosorbent assay method. Results: IL-17A levels were increased in parallel with the clinical condition in all patients. TGF-β1 was only observed in patients in Groups 3 and 4, and IL-6 was only observed in Group 4 patients. Conclusion: It is known that many cytokines are involved in the development of different viral infections and viral invasion always triggers an inflammatory response. The profile of inflammatory markers may be used to classify COVID-19 patients. In conclusion of this study, it is suggested that the level of cytokines which is changed according to the patient's clinical status should be used to evaluate the response of SARS-CoV-2 treatment. IL-17A, TGF-β1, and IL-6 concentrations in plasma levels could be good prognostic indicators of COVID-19. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2589627X |
| العلاقة: | Journal of Nature and Science of Medicine; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; Vatansever HS, Sayan M, Ozgul-Onal M, Akhan S, Ozel S, Sanlidag T. The relationship between coronavirus disease-2019-positive patients and plasma interleukins and transforming growth factor-β levels. J Nat Sci Med 2023;6:32-7.; https://hdl.handle.net/20.500.12809/10538Test; 32; 37 |
| الإتاحة: | https://doi.org/20.500.12809/10538Test https://hdl.handle.net/20.500.12809/10538Test |
| حقوق: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.BF0981B3 |
| قاعدة البيانات: | BASE |
| تدمد: | 2589627X |
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