دورية أكاديمية
Nigella sativa oil alleviates doxorubicin-induced cardiomyopathy and neurobehavioral changes in mice: In vivo and in-silico study
| العنوان: | Nigella sativa oil alleviates doxorubicin-induced cardiomyopathy and neurobehavioral changes in mice: In vivo and in-silico study |
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| المؤلفون: | Md Jamir Anwar, Sattam Khulaif Alenezi, Faizul Azam, Danish Mahmood, Faisal Imam, Khalid Saad Alharbi |
| المصدر: | Asian Pacific Journal of Tropical Biomedicine, Vol 12, Iss 7, Pp 312-322 (2022) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Arctic medicine. Tropical medicine LCC:Biology (General) |
| مصطلحات موضوعية: | nigella sativa oil, doxorubicin, cardiomyopathy, neurobehavioral changes, lactate dehydrogenase, creatinine kinase-mb, malondialdehyde, reduced glutathione, mice, hdac docking, Arctic medicine. Tropical medicine, RC955-962, Biology (General), QH301-705.5 |
| الوصف: | Objective: To investigate the effect of Nigella sativa oil on cardiomyopathy and neurobehavioral changes induced by doxorubicin in mice. Methods: Swiss strain of albino female mice were divided into 6 groups of 5 animals in each: Group I (control group), group II (doxorubicin, 10 mg/kg, i.v.), group III, IV, and V (Nigella sativa oil; 1.5, 3, and 6 mL/kg, respectively), group Ή (Nigella sativa oil per se; 6 mL/kg, p.o.). The duration of treatment was 15 d (10 days’ pre-treatment and 5 days’ post-treatment) and doxorubicin was administered on day 11th of the treatment schedule. Following Nigella sativa oil treatment, neurobehavioral tests, cardiac hypertrophy tests, and biochemical tests in serum and tissues were performed. Neurological tests included assessment of anxiety-like behavior in the elevated plus maze, spontaneous alternation behavior in the cross maze, and depression-like behavior in modified forced swim tests. Biochemical tests included serum lactate dehydrogenase and creatinine kinase-MB, malondialdehyde and reduced glutathione in tissues. Lastly, molecular docking was used to estimate the affinity of the phytoconstituents of Nigella sativa oil with histone deacetylases. Results: Nigella sativa oil treatment significantly (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2221-1691 2588-9222 |
| العلاقة: | http://www.apjtb.org/article.asp?issn=2221-1691;year=2022;volume=12;issue=7;spage=312;epage=322;aulast=AnwarTest; https://doaj.org/toc/2221-1691Test; https://doaj.org/toc/2588-9222Test |
| DOI: | 10.4103/2221-1691.350179 |
| الوصول الحر: | https://doaj.org/article/01729c015b8f4c069681792bd93226c6Test |
| رقم الانضمام: | edsdoj.01729c015b8f4c069681792bd93226c6 |
| قاعدة البيانات: | Directory of Open Access Journals |
| تدمد: | 22211691 25889222 |
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| DOI: | 10.4103/2221-1691.350179 |