Evaluation of a new serological test for syphilis based on chemiluminescence assay in a tertiary care hospital
| العنوان: | Evaluation of a new serological test for syphilis based on chemiluminescence assay in a tertiary care hospital |
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| المؤلفون: | Richa Bhargava, Aseem K Tiwari, Ravi C Dara, Prashant Pandey, Vimarsh Raina, Ganesh Rawat |
| المصدر: | Asian Journal of Transfusion Science, Vol 9, Iss 1, Pp 65-69 (2015) Asian Journal of Transfusion Science |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | law.invention, Serology, Antigen, law, medicine, Immunology and Allergy, Chemiluminescence, Chemiluminescence assay, Immunodiagnostics, Treponema, biology, business.industry, lcsh:RC633-647.5, Hematology, lcsh:Diseases of the blood and blood-forming organs, biology.organism_classification, medicine.disease, treponemal test, Non-treponemal test, serological test for syphilis, Immunology, biology.protein, Syphilis, Original Article, Antibody, business |
| الوصف: | Context: Syphilis is a transfusion transmissible infections and it is mandatory to do serological test for syphilis (STS) on all donor blood samples. STS is usually based on detection of antibodies against the cardiolipin-lecithin antigen or against the Treponema-specific antigen. STS with good sensitivity and specificity helps enhance blood safety and consolidation of STS along with other transfusion transmittable infections such as human immunodeficiency virus, hepatitis-C virus, and hepatitis-B virus helps in reducing the errors and enhances efficiency. Aims: This study was designed to evaluate the performance of newly introduced VITROS ® syphilis Treponema pallidum agglutination (TPA) assay based on enhanced chemiluminescence principle for its analytical performance for use as a STS on donor blood samples at a tertiary care health center in National Capital Region, India. Materials and Methods: A total of 108 random blood units collected from the donors (both voluntary and replacement donors) and 28 known syphilis sero-reactive samples stored at −20°C, were used to evaluate the performance of VITROS ® syphilis TPA assay based on enhanced chemiluminescence assay on VITROS ® ECiQ immunodiagnostics system along with its analytical performance in terms of its sensitivity, precision, cross-reactivity and interference studies. Results: VITROS ® syphilis TPA showed 100% sensitivity and specificity with precision (20 days study) of |
| اللغة: | English |
| تدمد: | 1998-3565 0973-6247 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17d00588322f4ab241cd1d0b1b8bff9Test http://www.ajts.org/article.asp?issn=0973-6247;year=2015;volume=9;issue=1;spage=65;epage=69;aulast=TiwariTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c17d00588322f4ab241cd1d0b1b8bff9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19983565 09736247 |
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