Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders
| العنوان: | Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders |
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| المؤلفون: | Sidharth Mehan, Shaba Parveen, Sanjeev Kalra |
| المصدر: | Neural Regeneration Research, Vol 12, Iss 2, Pp 290-300 (2017) Neural Regeneration Research |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Excitotoxicity, medicine.disease_cause, Neuroprotection, lcsh:RC346-429, forskolin, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Developmental Neuroscience, nerve regeneration, Huntington′s disease, mitochondria, adenyl cyclase, oxidative stress, basal ganglia, neural regeneration, Internal medicine, Lactate dehydrogenase, medicine, lcsh:Neurology. Diseases of the nervous system, Forskolin, biology, Neurodegeneration, Huntington's disease, Glutathione, medicine.disease, 030104 developmental biology, Endocrinology, chemistry, biology.protein, 030217 neurology & neurosurgery, Oxidative stress, Research Article |
| الوصف: | Long term suppression of succinate dehydrogenase by selective inhibitor 3-nitropropionic acid has been used in rodents to model Huntington's disease where mitochondrial dysfunction and oxidative damages are primary pathological hallmarks for neuronal damage. Improvements in learning and memory abilities, recovery of energy levels, and reduction of excitotoxicity damage can be achieved through activation of Adenyl cyclase enzyme by a specific phytochemical forskolin. In this study, intraperitoneal administration of 10 mg/kg 3-nitropropionic acid for 15 days in rats notably reduced body weight, worsened motor cocordination (grip strength, beam crossing task, locomotor activity), resulted in learning and memory deficits, greatly increased acetylcholinesterase, lactate dehydrogenase, nitrite, and malondialdehyde levels, obviously decreased adenosine triphosphate, succinate dehydrogenase, superoxide dismutase, catalase, and reduced glutathione levels in the striatum, cortex and hippocampus. Intragastric administration of forskolin at 10, 20, 30 mg/kg dose-dependently reversed these behavioral, biochemical and pathological changes caused by 3-nitropropionic acid. These results suggest that forskolin exhibits neuroprotective effects on 3-nitropropionic acid-induced Huntington's disease-like neurodegeneration. |
| اللغة: | English |
| تدمد: | 1673-5374 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1925c0cc74d483bf48aacc5fbb0dea36Test http://www.nrronline.org/article.asp?issn=1673-5374;year=2017;volume=12;issue=2;spage=290;epage=300;aulast=MehanTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1925c0cc74d483bf48aacc5fbb0dea36 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16735374 |
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