Protective effects of ginsenoside Rg1 against hydrogen peroxide-induced injury in human neuroblastoma cells
| العنوان: | Protective effects of ginsenoside Rg1 against hydrogen peroxide-induced injury in human neuroblastoma cells |
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| المؤلفون: | Miao Geng, Cheng-yong Xu, Zhi-gao Sun, Liping Chen, Fa-wei Wang |
| المصدر: | Neural Regeneration Research, Vol 11, Iss 7, Pp 1159-1164 (2016) Neural Regeneration Research |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, caspase-3, traditional Chinese medicine monomer, H2O2, Caspase 3, Pharmacology, SH-SY5Y cells, cerebral ischemia, lcsh:RC346-429, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, Ginseng, 0302 clinical medicine, nerve regeneration, ginsenoside Rg1, cell apoptosis, lactate dehydrogenase, superoxide dismutase, heat shock protein 70, dose-effect relationship, neural regeneration, Developmental Neuroscience, Lactate dehydrogenase, Medicine, Hydrogen peroxide, lcsh:Neurology. Diseases of the nervous system, biology, business.industry, Hsp70, 030104 developmental biology, chemistry, Biochemistry, Mechanism of action, Apoptosis, biology.protein, medicine.symptom, business, 030217 neurology & neurosurgery, Research Article |
| الوصف: | The active ingredient of ginseng, ginsenosides Rg1, has been shown to scavenge free radicals and improve antioxidant capacity. This study hypothesized that ginsenosides Rg1 has a protective role in human neuroblastoma cells injured by H2O2. Ginsenosides Rg1 at different concentrations (50 and 100 μM) was used to treat H2O2 (150 μM)-injured SH-SY5Y cells. Results demonstrated that ginsenoside Rg1 elevated the survival rate of SH-SY5Y cells injured by H2O2, diminished the amount of leaked lactate dehydrogenase, and increased superoxide dismutase activity. Ginsenoside Rg1 effectively suppressed caspase-3 immunoreactivity, and contributed to heat shock protein 70 gene expression, in a dose-dependent manner. These results indicate that ginsenoside Rg1 has protective effects on SH-SY5Y cells injured by H2O2 and that its mechanism of action is associated with anti-oxidation and the inhibition of apoptosis. |
| اللغة: | English |
| تدمد: | 1673-5374 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c27539bea00d23cf9b1d5787dcd407f7Test http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=7;spage=1159;epage=1164;aulast=SunTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c27539bea00d23cf9b1d5787dcd407f7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16735374 |
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