The Association of Psoriasis and Obesity: Focusing on IL-17A-Related Immunological Mechanisms

التفاصيل البيبلوغرافية
العنوان:	The Association of Psoriasis and Obesity: Focusing on IL-17A-Related Immunological Mechanisms
المؤلفون:	Cheng Xu, Jie Ji, Ting Su, Hong-Wei Wang, Zhong-Lan Su
المصدر:	International Journal of Dermatology and Venerology, Vol 4, Iss 2, Pp 116-121 (2021)
بيانات النشر:	Wolters Kluwer Health
سنة النشر:	2021
المجموعة:	Directory of Open Access Journals: DOAJ Articles
مصطلحات موضوعية:	Dermatology, RL1-803
الوصف:	Psoriasis is a chronic, recurrent, inflammatory skin disease that is often accompanied by obesity. An increasing amount of research has elucidated the pathophysiological link between psoriasis and obesity. Since 2005, interleukin (IL)-17-producing T helper 17 cells and their main effector cytokine IL-17A have been considered to play a critical role in the pathogenesis of psoriasis; the marked effect of biotherapies targeting IL-17A on moderate and severe psoriasis has further established its role in psoriasis. Recent studies have found that obesity induces T helper 17 cells to secrete IL-17A and participate in the pathogenesis of psoriasis. IL-17A may be a crucial element in the association between psoriasis and obesity. This review discusses the association between psoriasis and obesity, with a focus on and the implications regarding the need to treat psoriasis.
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
تدمد:	2096-5540 2641-8746
العلاقة:	http://journals.lww.com/10.1097/JD9.0000000000000155Test; https://doaj.org/toc/2096-5540Test; https://doaj.org/toc/2641-8746Test; https://doaj.org/article/b2cc4ffd29aa4ddf92842210722324e3Test
DOI:	10.1097/JD9.0000000000000155
الإتاحة:	https://doi.org/10.1097/JD9.0000000000000155Test https://doaj.org/article/b2cc4ffd29aa4ddf92842210722324e3Test
رقم الانضمام:	edsbas.39D8DBDA
قاعدة البيانات:	BASE

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الوصف
تدمد:	20965540 26418746
DOI:	10.1097/JD9.0000000000000155