Nimotuzumab with intensity-modulated radiation therapy in unresectable and platinum-ineligible locally advanced head-and-neck cancer
| العنوان: | Nimotuzumab with intensity-modulated radiation therapy in unresectable and platinum-ineligible locally advanced head-and-neck cancer |
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| المؤلفون: | C V Divyambika, K. Satish Srinivas, Raja Sundaram, Sameer Chaudhari |
| المصدر: | South Asian Journal of Cancer South Asian Journal of Cancer, Vol 09, Iss 01, Pp 43-46 (2020) |
| بيانات النشر: | Wolters Kluwer - Medknow, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | head-and-neck neoplasms, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, overall survival, monoclonal, carcinoma, lcsh:RC254-282, 03 medical and health sciences, 0302 clinical medicine, medicine, Carcinoma, Nimotuzumab, antibodies, Adverse effect, Survival rate, platinum ineligible, 0303 health sciences, Chemotherapy, therapy, 030306 microbiology, business.industry, nimotuzumab, squamous cell, ORIGINAL ARTICLE: Head and Neck Cancers, Head and neck cancer, Cancer, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Radiation therapy, Oncology, 030220 oncology & carcinogenesis, Advanced, Radiology, inoperable, business, medicine.drug |
| الوصف: | Background: Outcomes with conventional treatment are poor in patients with squamous cell carcinoma of head and neck (SCCHN). Treatment options are further limited for patients ineligible to receive platinum-based chemotherapy due to various factors such as geriatric age, comorbidity, and organ dysfunctions. The present study retrospectively evaluated the effectiveness of nimotuzumab when added to radiation therapy in unresectable, locally advanced SCCHN patients who were ineligible for platinum-based chemotherapy. Materials and Methods: The medical records of 21 patients with unresectable, locally advanced head-and-neck cancer and histologically confirmed squamous cell carcinoma who were ineligible for platinum-based chemotherapy treated with nimotuzumab and intensity-modulated radiation therapy (IMRT) from 2012 to 2017 were retrospectively analyzed. The tumor response rate and overall survival (OS) were analyzed. Patients were assessed for toxicity and adverse events (AEs) as per CTCAE version 4. Statistical analysis was performed using SPSS software. Results: The median number of doses of nimotuzumab received was 6, and median dose of radiotherapy was 60 Gy. The tumor response rate was calculated at 24 weeks after the completion of radiotherapy and was as follows: 76.2% (16) of patients showed complete response, 9.5% (2) of patients showed partial response, 4.8% (1) of patients showed stable disease, and 9.5% (2) of patients showed progression of disease. Median OS was 21 months, whereas 1-year survival rate was 63.7%. No Grade 3 or Grade 4 AEs were observed. Conclusion: Nimotuzumab with IMRT has achieved promising clinical outcomes in unresectable locally advanced SCCHN patients who are ineligible for platinum-based chemotherapy, without accumulation of toxicity. |
| اللغة: | English |
| تدمد: | 2278-4306 2278-330X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fed3da05c51c7f690c4f20d39905b50fTest http://europepmc.org/articles/PMC6956585Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fed3da05c51c7f690c4f20d39905b50f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22784306 2278330X |
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