دورية أكاديمية
Sutureless Transplantation of Amniotic Membrane Using a Visible Light-Curable Protein Bioadhesive for Ocular Surface Reconstruction
| العنوان: | Sutureless Transplantation of Amniotic Membrane Using a Visible Light-Curable Protein Bioadhesive for Ocular Surface Reconstruction |
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| المساهمون: | Seong-Woo Maeng, Tae Yoon Park, Ji Sang Min, Longyu Jin, Kye Il Joo, Woo Chan Park, Hyung Joon Cha, Min, Ji Sang |
| بيانات النشر: | Wiley-VCH |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Amnion* / transplantation, Animals, Conjunctiva, Light, Pterygium* / surgery, Rabbits, Tissue Adhesives, amniotic membrane transplantations, conjunctivas, mussel adhesive proteins, ocular surface reconstructions, visible light-curable bioadhesives |
| الوصف: | The conjunctiva is a thin mucous membrane of the eye. Pterygium, a commonly appearing disease on the ocular surface, requires surgery to excise the conjunctiva to prevent visual deterioration. Recently, transplantation of the amniotic membrane (AM), which is the innermost membrane of the placenta, has been highlighted as an efficient method to cure conjunctiva defects because of its advantages of no side effects compared to mitomycin C treatment and not leaving additional scars on donor site compared to conjunctival autografting. However, to minimize additional damage to the ocular surface by suturing, AM transplantation (AMT) needs to be simplified by using a less invasive, time-saving method. In this work, a visible light-curable protein bioadhesive (named FixLight) for efficient sutureless AMT is applied. FixLight, which is based on bioengineered mussel adhesive protein (MAP), is easily applied between damaged ocular surfaces and transplanted AM, and rapidly cured by harmless blue light activation. Through in vivo evaluation using a rabbit model, the authors demonstrated that FixLight enabled facile, fast, and strong attachment of AM on sclera and promoted ocular surface reconstruction with good biocompatibility. Thus, FixLight can be successfully used as a promising clinical bioadhesive in opthalmological surgeries that require sutureless and rapid operation. ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2192-2640 2192-2659 |
| العلاقة: | ADVANCED HEALTHCARE MATERIALS; J00042; OAK-2022-04969; https://ir.ymlib.yonsei.ac.kr/handle/22282913/190842Test; T9992022253; ADVANCED HEALTHCARE MATERIALS, Vol.10(13), 2021-07 |
| DOI: | 10.1002/adhm.202100100 |
| الإتاحة: | https://doi.org/10.1002/adhm.202100100Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/190842Test |
| حقوق: | CC BY-NC-ND 2.0 KR |
| رقم الانضمام: | edsbas.71F4BAC9 |
| قاعدة البيانات: | BASE |
| تدمد: | 21922640 21922659 |
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| DOI: | 10.1002/adhm.202100100 |