دورية أكاديمية
A polygenic model with common variants may predict lung adenocarcinoma risk in humans
| العنوان: | A polygenic model with common variants may predict lung adenocarcinoma risk in humans |
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| المؤلفون: | A. Galvan, F. S. Falvella, M. Spinola, E. Frullanti, V. P. Leoni, M. R. Alonso, U. Pastorino, M. Incarbone, A. G. Neira, T. A. Dragani, NOCI, SARA, A. Zolin, E. Spada, S. Milani, L. Santambrogio |
| المساهمون: | A. Galvan, F.S. Falvella, M. Spinola, E. Frullanti, V.P. Leoni, S. Noci, M.R. Alonso, A. Zolin, E. Spada, S. Milani, U. Pastorino, M. Incarbone, L. Santambrogio, A.G. Neira, T.A. Dragani |
| بيانات النشر: | Wiley-Liss |
| سنة النشر: | 2008 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | Genetic susceptibility, Genome-wide association, Lung adenocarcinoma, Single-nucleotide polymorphism, Smoking, Settore MED/01 - Statistica Medica, Settore MED/21 - Chirurgia Toracica |
| الوصف: | Genome-wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single-nucleotide polymorphism (SNP)array, in a joint analysis of 2 Italian case–control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6–0.8]. In a polygenic model characterized by additive and interchangeable effects, individuals carrying 2 to 6 rare alleles at these 8 SNPs showed a significant trend toward a decreased risk of lung ADCA (up to OR of 0.3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/18729187; info:eu-repo/semantics/altIdentifier/wos/WOS:000260443300013; volume:123; issue:10; firstpage:2327; lastpage:2330; journal:INTERNATIONAL JOURNAL OF CANCER; http://hdl.handle.net/2434/52183Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-53449085065 |
| DOI: | 10.1002/ijc.23789 |
| الإتاحة: | https://doi.org/10.1002/ijc.23789Test http://hdl.handle.net/2434/52183Test |
| رقم الانضمام: | edsbas.5519B335 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ijc.23789 |
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