مورد إلكتروني
Serum immunoglobulin G directed against porcine trypsin in the serum of cystic fibrosis children receiving porcine pancreatic enzyme supplements
| العنوان: | Serum immunoglobulin G directed against porcine trypsin in the serum of cystic fibrosis children receiving porcine pancreatic enzyme supplements |
|---|---|
| المصدر: | Journal of Paediatrics and Child Health |
| بيانات النشر: | Wiley-Blackwell Publishing Ltd 1993 |
| تفاصيل مُضافة: | Quirk, P. Greer, R. Shepherd, R. Cleghorn, Geoffrey J. |
| نوع الوثيقة: | Electronic Resource |
| مستخلص: | Cystic fibrosis (CF) patients require pancreatic enzyme replacement therapy to correct pancreatic insufficiency. These enzymes are derived from porcine pancreas and are known to be antigenic. To determine the possible clinical consequences, a specific ELISA was developed to detect IgG antibody directed against porcine trypsin (PTAb) in the sera of CF patients. The assay was used to evaluate the occurrence of PTAb in a cross sectional study of 103 CF patients in relation to the introduction of porcine enzyme therapy, clinical status and genotype. Antibodies against porcine trypsin were detected in the sera of 63% of patients unrelated to the age of commencement or the duration of enzyme therapy. No differences were observed in the clinical status of CF patients who had developed PTAb (n = 65) and those who had no detectable PTAb (n = 38) as determined from: the current prescribed dose of porcine pancreatic enzyme capsules; Z scores for height and weight; and respiratory function tests. It is suggested that the PTAb commonly found in the sera of CF patients are of doubtful clinical significance but the prospect of PTAb contributing to immune complex disease should be examined further. |
| مصطلحات الفهرس: | cystic fibrosis, immunoglobulin G, pancreatic enzyme supplements, porcine trypsin, immunoglobulin g antibody, pancreas enzyme, trypsin, antibody detection, antigenicity, article, enzyme linked immunosorbent assay, human, major clinical study, pancreas exocrine insufficiency, priority journal, Adolescent, Animal, Child, Preschool, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Pancreatic Extracts, Pancreatic Insufficiency, Swine, Contribution to Journal |
| URL: | Quirk, P., Greer, R., Shepherd, R., & Cleghorn, Geoffrey J. (1993) Serum immunoglobulin G directed against porcine trypsin in the serum of cystic fibrosis children receiving porcine pancreatic enzyme supplements. Journal of Paediatrics and Child Health, 29(3), pp. 196-200. |
| الإتاحة: | Open access content. Open access content Consult author(s) regarding copyright matters This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| أرقام أخرى: | ATUTQ oai:eprints.qut.edu.au:90014 Faculty of Health; Institute of Health and Biomedical Innovation 931768410 |
| المصدر المساهم: | QUEENSLAND UNIV OF TECH From OAIster®, provided by the OCLC Cooperative. |
| رقم الانضمام: | edsoai.ocn931768410 |
| قاعدة البيانات: | OAIster |
| الوصف غير متاح. |