المؤلفون: Inomata, Satomi¹, Yoshida, Taketoshi¹ ytake@med.u-toyama.ac.jp, Nagaoka, Mitsuhide¹, Yasuda, Ippei², Aoki, Aiko², Tamura, Kentaro¹, Kawasaki, Yukako¹, Makimoto, Masami¹, Matsumura, Kenta³, Adachi, Yuichi⁴

المصدر: Journal of Obstetrics & Gynaecology Research. Dec2022, Vol. 48 Issue 12, p3119-3127. 9p.

مصطلحات موضوعية: *MAGNESIUM sulfate, *ALKALINE phosphatase, *THIRD trimester of pregnancy, *PHOSPHORUS, *TREATMENT effectiveness, *BONE density, *PRENATAL care, *SECOND trimester of pregnancy, *CALCIUM, *CHILDREN, *PREGNANCY

مستخلص: Aim: To evaluate the relationship between long‐term antenatal magnesium sulfate (MgSO4) administration and neonatal bone mineralization. Methods: Infants born at 28–33 weeks of gestation (n = 163) were divided into three groups: long‐term Mg administration group (infants received antenatal MgSO4 for ≥40 days), short‐term Mg administration group (infants received antenatal MgSO4 for <40 days), and non‐Mg group. Serum calcium, phosphorus, Mg, and alkaline phosphatase were measured weekly up to 1 month of age, and the bone speed of sound (SOS) values were measured using quantitative ultrasound (QUS) at 1 week and 1 month after birth. Results: In the long‐term Mg administration group, the serum calcium values were significantly lower, and the serum phosphorus, Mg, and alkaline phosphatase values were significantly higher than those in the non‐Mg group at birth. Although these biochemical differences disappeared around the age of 2 weeks, the SOS values of the long‐term Mg administration group were significantly lower than those of the non‐Mg group both at 1 week and 1 month after birth (p = 0.02 and <0.001, respectively). When less than 10th percentile of SOS values at 1 month after birth in the non‐Mg group was defined as poor bone mineralization, the cut‐off value for the duration of antenatal MgSO4 administration was 67 days. Conclusions: Long‐term antenatal MgSO4 administration affects bone mineralization during the early neonatal period, but the clinically acceptable duration of the administration based on its effects of bone mineralization assessed with QUS might be longer than a few weeks. [ABSTRACT FROM AUTHOR]

المؤلفون: Yoshida, Taketoshi¹ ytake@med.u-toyama.ac.jp, Hiraiwa, Akiko², Ibuki, Keijiro¹, Makimoto, Masami¹, Inomata, Satomi¹, Tamura, Kentaro¹, Kawasaki, Yukako¹, Ozawa, Sayaka², Hirono, Keiichi², Ichida, Fukiko²

المصدر: Pediatrics International. Jul2020, Vol. 62 Issue 7, p797-803. 7p. 1 Diagram, 6 Charts.

مصطلحات موضوعية: *COGNITION disorders diagnosis, *MENTAL illness risk factors, *LANGUAGE disorder diagnosis, *LOW birth weight, *CONGENITAL heart disease, *HEART ventricles, *MOVEMENT disorders, *RISK assessment, *SURGICAL complications, *DISEASE complications, DIAGNOSIS of developmental disabilities

مستخلص: Background: Both congenital heart disease (CHD) and very‐low birthweight (VLBW) infants are at a very high risk of neurodevelopmental delay. We investigated neurological development at 3 years in pediatric patients with CHD after surgical intervention, those of VLBW, and healthy controls. Methods: We enrolled pediatric patients with CHD (n = 67), VLBW (n = 67), and healthy controls (n = 81). Infants with CHD were grouped into those with single ventricle and two ventricles, and infants with VLBW were grouped into those with birthweights of <1000 and 1000–1499 g. Neurodevelopmental outcomes at 3 years were evaluated using the Bayley Scales of Infant and Toddler Development, Third Edition. Results: Compared with healthy controls, a significant deficit in the language, cognition, and motor skills scores were observed in infants with CHD and VLBW. Infants with a single ventricle exhibited significantly low scores in language and gross motor skills. No statistically significant difference was observed between the birthweight groups of <1000 and 1000–1499 g. Conclusion: Neurodevelopmental outcomes for infants with both CHD and VLBW showed impairment. Notably, neurodevelopmental delays in infants with a single ventricle were remarkable. Thus, because infants with both CHD and VLBW are at high risk of neurodevelopmental disorders, periodic developmental screenings and support are warranted for these children. [ABSTRACT FROM AUTHOR]

المؤلفون: Yoshida, Taketoshi¹, Inomata, Satomi¹, Tamura, Kentaro¹, Makimoto, Masami¹, Kawasaki, Yukako^1,2, Oishi, Kenichi², Matsui, Mie³, Hiraiwa, Akiko⁴

المصدر: Journal of Neuroimaging. Jan2019, Vol. 29 Issue 1, p104-110. 7p.

مصطلحات موضوعية: *BRAIN anatomy, *MAGNETIC resonance imaging, *BIRTH weight, *DOLICHOCEPHALY, *REGRESSION analysis

مستخلص: Background and Purpose: Measuring head circumference (HC) in infants is an easy screening procedure with which to detect abnormalities in brain growth. It has been demonstrated that HC can predict total brain volume (TBV) in very-low-birth-weight (VLBW) infants. However, the correlation between HC and TBV was weaker than that observed in healthy term-born toddlers, suggesting that there are factors that influence the relationship between HC and TBV. The aim of this study was to identify the clinical risk factors that caused a deviation from the regression line obtained between HC and TBV.Methods: The study population was based on 37 VLBW infants, who underwent a clinical magnetic resonance imaging (MRI) examination at a term-equivalent age, during 2013-2015, at Toyama University Hospital. The HC and the TBV were both adjusted for sex, multiple births, and postmenstrual age. The relationship between TBV/HC and clinical characteristics was evaluated.Results: There was a positive correlation between HC and TBV (r = .58, P = .000168). Two clinical factors, the lower birth body weight (BBW) (r = .38, P = .02) and dolichocephaly (r = 0.46, P = .006), were identified as factors that negatively affected the TBV/HC ratio. After excluding infants with low BBW or with dolichocephaly, the correlation between HC and TBV was higher (r = .63).Conclusions: Although HC has predictive value for TBV in VLBW infants, care should be taken in infants with low BBW (BBW less than 600 g) or dolichocephaly (MRI-based cranial index less than .68), which were related to overestimation of TBV. [ABSTRACT FROM AUTHOR]

المؤلفون: Yoneda, Satoshi, Yoneda, Noriko, Shiozaki, Arihiro, Yoshino, Osamu, Ueno, Tomohiro, Niimi, Hideki, Kitajima, Isao, Tamura, Kentaro, Kawasaki, Yukako, Makimoto, Masami, Yoshida, Taketoshi, Saito, Shigeru

المصدر: American Journal of Reproductive Immunology; Sep2018, Vol. 80 Issue 3, p1-1, 11p

مصطلحات موضوعية: PREMATURE labor, AMNIOTIC liquid, INFLAMMATION, 17-hydroxyprogesterone, INTERLEUKINS

مستخلص: Problem: It is not known whether 17‐alpha‐hydroxyprogesterone caproate (17OHP‐C) is effective for preventing preterm delivery with an episode of preterm labor (PTL) with or without intra‐amniotic inflammation/infection. Methods of study: This was a retrospective cohort study. One hundred and seven PTL patients were selected and divided into a 17OHP‐C group (use of 17OHP‐C: n = 53) and a no‐treatment group (no use of 17OHP‐C: n = 54). Moreover, the patients were divided into three subgroups (subgroup A: without intra‐amniotic inflammation, B: with mild intra‐amniotic inflammation, and C: with severe intra‐amniotic inflammation) according to their level of amniotic interleukin (IL)‐8, and perinatal prognosis was analyzed. Results: Interval from admission to delivery (days) in the 17OHP‐C group (76 [13‐126], n = 34) was significantly longer than that in the no‐treatment group (50 [8‐104], n = 33; P = .012) in subgroup B. In cases without intra‐amniotic microbes in subgroup B, a significant prolongation of gestational days was associated with the 17OHP‐C group (79 [13‐126], n = 25) compared with the no‐treatment group (50 [8‐104], n = 29; P = .029). However, there were no significant differences in subgroups A or C. Conclusion: 17OHP‐C could prolong gestational period in limited PTL cases with sterile mild intra‐amniotic inflammation. [ABSTRACT FROM AUTHOR]

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المؤلفون: Zhang, Wen, Du, Yuhang, Yoshida, Taketoshi, Wang, Qing, Li, Xiangjun

المصدر: IET Software (Wiley-Blackwell); Jun2018, Vol. 12 Issue 3, p183-189, 7p

مستخلص: Monitoring and predicting the trend of bug number time series of a software system is crucial for both software project managers and software end‐users. For software managers, accurate prediction of bug number of a software system will assist them in making timely decisions, such as effort investment and resource allocation. For software end‐users, knowing possible bug number of their systems ahead will enable them to adopt timely actions in coping with the loss caused by possible system failures. This study proposes an approach called SamEn‐SVR to combine sample entropy and support vector regression (SVR) to predict software bug number using time series analysis. The basic idea is to use template vectors with the smallest complexity as input vectors for SVR classifiers to ensure predictability of time series. By using Mozilla Firefox bug data, we conduct extensive experiments to compare the proposed approach and state‐of‐the‐art techniques including auto‐regressive integrated moving average (ARIMA), X12 enhanced ARIMA and polynomial regression to predict bug number time series. Experimental results demonstrate that the proposed SamEn‐SVR approach outperforms state‐of‐the‐art techniques in bug number prediction. [ABSTRACT FROM AUTHOR]

: Copyright of IET Software (Wiley-Blackwell) is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Yoneda, Satoshi, Yoneda, Noriko, Fukuta, Kaori, Shima, Tomoko, Nakashima, Akitoshi, Shiozaki, Arihiro, Yoshino, Osamu, Kigawa, Mika, Yoshida, Taketoshi, Saito, Shigeru

المصدر: Journal of Obstetrics & Gynaecology Research; Mar2018, Vol. 44 Issue 3, p397-407, 11p, 1 Diagram, 5 Charts, 2 Graphs

مصطلحات موضوعية: PREVENTION of pregnancy complications, AMNIOTIC liquid, CONFIDENCE intervals, HOSPITAL admission & discharge, HUMAN reproductive technology, PREMATURE infants, INTERLEUKINS, INTRAVENOUS therapy, EVALUATION of medical care, MAGNESIUM sulfate, PATIENTS, PREGNANCY, MULTIPLE regression analysis, RITODRINE, BODY mass index, ODDS ratio, CERVICAL cerclage, THERAPEUTICS

مستخلص: Abstract: Aim: We evaluated whether maintenance tocolysis (intravenous ritodrine hydrochloride and/or magnesium sulfate) was effective in cases of spontaneous preterm labor with intact membranes. Methods: One hundred and thirty preterm labor patients who reached 36 weeks of gestation by maintenance tocolysis were selected. Immediate delivery (ID) after ceasing maintenance tocolysis was defined as an ‘effective case’. The correlated factors between ID and no immediate delivery (NID) were statistically analyzed. Results: Thirty‐six patients delivered < two days after ceasing maintenance tocolysis (27.7%) and were defined as effective cases. Multiple logistic regression analysis revealed that amniotic fluid interleukin‐8 at admission (≥ 2.3 ng/mL; odds ratio [OR] 5.6, 95% confidence interval [CI] 2.1–17.6; P < 0.001), pre‐pregnancy body mass index (≤ 21.4; OR 5.3, 95% CI 2.0–16.2; P < 0.001) and cerclage (OR 3.6, 95% CI 1.1–11.8; P = 0.028) were independent factors correlated with ID (< 2 days). Conclusion: Maintenance tocolysis may be effective in limited cases with mild intra‐amniotic inflammation, in lean women and in cerclage cases. Maintenance tocolysis should be ceased in cases without these clinical factors when clinical symptoms disappear. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Obstetrics & Gynaecology Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Inomata, Satomi¹, Yoshida, Taketoshi¹, Koura, Uta¹, Tamura, Kentaro¹, Hatasaki, Kiyoshi², Imamura, Hiroaki³, Mase, Daisuke⁴, Kigawa, Mika⁵, Adachi, Yuichi⁶, Inadera, Hidekuni⁵

المصدر: Pediatrics International. Dec2015, Vol. 57 Issue 6, p1126-1130. 5p.

مصطلحات موضوعية: *ACADEMIC medical centers, *BLOOD pressure, *BODY weight, *CARDIOVASCULAR diseases risk factors, *CHI-squared test, *HUMAN growth, *PREMATURE infants, *LIPIDS, *LONGITUDINAL method, *RESEARCH funding, *STATURE, *MULTIPLE regression analysis, *BODY mass index, *RETROSPECTIVE studies, *CASE-control method, *DATA analysis software, *DESCRIPTIVE statistics, *MANN Whitney U Test

مصطلحات جغرافية: JAPAN

مستخلص: Background: Low birthweight is associated with increased risk for cardiovascular disease (CVD) in later life, but whether premature birth is also a risk factor for CVD has not been fully determined. The aim of this study was to investigate the relationship between gestational age and risk factors for CVD at school age. Methods: Using medical check-up data of school children, the relationship between gestational age and height, weight, body mass index, blood pressure, and lipid profiles at ages 9 and 12 years were investigated in children born preterm and admitted to neonatal intensive care unit at birth (n = 182; 115 boys and 67 girls). These data were also compared between preterm small for gestational age (SGA) children and preterm appropriate for gestational age (AGA) children. Results: Gestational age was positively associated with height, and inversely associated with systolic blood pressure at school age. Preterm SGA children were significantly shorter and lighter at 9 and 12 years of age compared with preterm AGA children, but there were no significant differences in any CVD risk factors between the groups. Conclusions: In preterm infants, a shorter duration of gestation is associated with higher systolic blood pressure at school age. [ABSTRACT FROM AUTHOR]

المؤلفون: Koura, Uta, Horikawa, Shinjiro, Okabe, Mako, Kawasaki, Yukako, Makimoto, Masami, Mizuta, Koichi, Yoshida, Taketoshi

المصدر: Clinical Case Reports; Aug2015, Vol. 3 Issue 8, p690-693, 4p

مصطلحات موضوعية: HEMOCHROMATOSIS, INBORN errors of metabolism, DYSGENESIS, PREMATURE infants, KIDNEY failure

مستخلص: Key Clinical Message We report the first surviving case of neonatal hemochromatosis with renal tubular dysgenesis. Renal failure was treated with peritoneal dialysis. Although hepatic failure from neonatal hemochromatosis was progressive, repeated exchange transfusions improved jaundice and coagulopathy. The patient gained weight and received a liver transplantation from her father. [ABSTRACT FROM AUTHOR]

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المؤلفون: Kawasaki, Yukako, Makimoto, Masami, Nomura, Keiko, Hoshino, Akihiro, Hamashima, Takeru, Hiwatari, Mitsuteru, Nakazawa, Atsuko, Takita, Junko, Yoshida, Taketoshi, Kanegane, Hirokazu

المصدر: Clinical Case Reports; Mar2015, Vol. 3 Issue 3, p145-149, 5p, 2 Color Photographs, 2 Black and White Photographs

مصطلحات موضوعية: NEWBORN infants, ACUTE leukemia, ENOLASE, GENE fusion

مستخلص: Key Clinical Message We describe a neonate with abdominal distension, massive hepatomegaly, and high serum neuron-specific enolase level suggestive of congenital neuroblastoma. The patient died of pulmonary hemorrhage after therapy. Autopsy revealed that the tumor cells in the liver indicated acute megakaryocytic leukemia with the RBM15- MKL1 fusion gene. [ABSTRACT FROM AUTHOR]

: Copyright of Clinical Case Reports is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Yoshida, Taketoshi¹, Takasaki, Ichiro², Kanegane, Hirokazu³, Inomata, Satomi¹, Ito, Yasunori³, Tamura, Kentaro¹, Makimoto, Masami¹, Saito, Shigeru⁴, Yoshimoto, Yuko⁵, Miyawaki, Toshio³

المصدر: Pediatrics International. Aug2014, Vol. 56 Issue 4, p559-565. 7p. 1 Diagram, 3 Charts, 1 Graph.

مصطلحات موضوعية: *TYPE 2 diabetes risk factors, *FETAL growth retardation, *RNA analysis, *BIRTH size, *CARDIOVASCULAR diseases risk factors, *CORD blood, *GENE expression, *POLYMERASE chain reaction, *RESEARCH funding, *T-test (Statistics), *BIOCHIPS, *CASE-control method, *DATA analysis software, *GENETICS

مستخلص: Background Small-for-gestational-age ( SGA) newborns are at an increased risk for perinatal morbidity and mortality and development of metabolic syndromes such as cardiovascular disease and type 2 diabetes mellitus ( T2 DM) in adulthood. The mechanism underlying this increased risk remains unclear. In this study, genetic modifications of cord blood were investigated to characterize fetal change in SGA newborns. Methods Gene expression in cord blood cells was compared between 10 SGA newborns and 10 appropriate-for-gestational-age ( AGA) newborns using microarray analysis. Pathway analysis was conducted using the Ingenuity Pathways Knowledge Base. To confirm the microarray analysis results, quantitative real-time polymerase chain reaction ( RT- PCR) was performed for upregulated genes in SGA newborns. Results In total, 775 upregulated and 936 downregulated probes were identified in SGA newborns and compared with those in AGA newborns. Of these probes, 1149 were annotated. Most of these genes have been implicated in the development of cardiovascular disease and T2 DM. There was good agreement between the RT- PCR and microarray analyses results. Conclusions Expression of certain genes was modified in SGA newborns in the fetal period. These genes have been associated with metabolic syndrome. To clarify the association between modified gene expression in cord blood and individual vulnerability to metabolic syndrome in adulthood, these SGA newborns will be have long-term follow up for examination of genetic and postnatal environmental factors. Gene expression of cord blood can be a useful and non-invasive method of investigation of genetic alterations in the fetal period. [ABSTRACT FROM AUTHOR]