التفاصيل البيبلوغرافية
| العنوان: |
Increased brain gyrification in the schizophrenia spectrum. |
| المؤلفون: |
Sasabayashi, Daiki1 (AUTHOR) ds179@med.u-toyama.ac.jp, Takayanagi, Yoichiro1 (AUTHOR), Takahashi, Tsutomu1 (AUTHOR), Nemoto, Kiyotaka2 (AUTHOR), Furuichi, Atsushi1 (AUTHOR), Kido, Mikio1 (AUTHOR), Nishikawa, Yumiko1 (AUTHOR), Nakamura, Mihoko1 (AUTHOR), Noguchi, Kyo3 (AUTHOR), Suzuki, Michio1 (AUTHOR) |
| المصدر: |
Psychiatry & Clinical Neurosciences. Jan2020, Vol. 74 Issue 1, p70-76. 7p. 1 Diagram, 2 Charts. |
| مصطلحات موضوعية: |
*MAGNETIC resonance imaging, *SCHIZOPHRENIA, *PEOPLE with schizophrenia, *NEURAL development |
| مستخلص: |
Aim: Increased brain gyrification in diverse cortical regions has been reported in patients with schizophrenia, possibly reflecting deviations in early neurodevelopment. However, it remains unknown whether patients with schizotypal disorder exhibit similar changes. Methods: This magnetic resonance imaging study investigated brain gyrification in 46 patients with schizotypal disorder (29 male, 17 female), 101 patients with schizophrenia (55 male, 46 female), and 77 healthy controls (44 male, 33 female). T1‐weighted magnetic resonance images were obtained for each participant. Using FreeSurfer software, the local gyrification index (LGI) of the entire cortex was compared across the groups. Results: Both schizophrenia and schizotypal disorder patients showed a significantly higher LGI in diverse cortical regions, including the bilateral prefrontal and left parietal cortices, as compared with controls, but its extent was broader in schizophrenia especially for the right prefrontal and left occipital regions. No significant correlations were found between the LGI and clinical variables (e.g., symptom severity, medication) for either of the patient groups. Conclusion: Increased LGI in the frontoparietal regions was common to both patient groups and might represent vulnerability to schizophrenia, while more diverse changes in schizophrenia patients might be associated with the manifestation of florid psychosis. [ABSTRACT FROM AUTHOR] |
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