التفاصيل البيبلوغرافية
| العنوان: |
Nutritional strategies for correcting low glucose values in patients with postbariatric hypoglycaemia: A randomized controlled three‐arm crossover trial. |
| المؤلفون: |
Schönenberger, Katja A.1,2 (AUTHOR), Ferreira, Antonio1 (AUTHOR), Stebler, Céline1 (AUTHOR), Prendin, Francesco3 (AUTHOR), Gawinecka, Joanna4 (AUTHOR), Nakas, Christos T.5,6 (AUTHOR), Mühlebach, Stefan2 (AUTHOR), Stanga, Zeno1 (AUTHOR), Facchinetti, Andrea3 (AUTHOR), Herzig, David1 (AUTHOR), Bally, Lia1 (AUTHOR) lia.bally@insel.ch |
| المصدر: |
Diabetes, Obesity & Metabolism. Oct2023, Vol. 25 Issue 10, p2853-2861. 9p. |
| مصطلحات موضوعية: |
*INSULIN aspart, *CROSSOVER trials, *HYPOGLYCEMIA, *BLOOD sugar, *GLUCOSE, *GASTRIC bypass, *HYPERGLYCEMIA |
| مستخلص: |
Aim: To evaluate the efficacy of nutritional hypoglycaemia correction strategies in postbariatric hypoglycaemia (PBH) after Roux‐en‐Y gastric bypass (RYGB). Materials and methods: In a randomized, controlled, three‐arm crossover trial, eight post‐RYGB adults (mean [SD] 7.0 [1.4] years since surgery) with PBH ingested a solid mixed meal (584 kcal, 85 g carbohydrates, 21 g fat, 12 g protein) to induce hypoglycaemia on three separate days. Upon reaching plasma glucose of less than 3.0 mmol/L, hypoglycaemia was corrected with 15 g of glucose (G15), 5 g of glucose (G5) or a protein bar (P10, 10 g of protein) in random order. The primary outcome was percentage of time spent in the target plasma glucose range (3.9‐5.5 mmol/L) during 40 minutes after correction. Results: Postcorrection time spent in the target glucose range did not differ significantly between the interventions (P =.161). However, postcorrection time with glucose less than 3.9 mmol/L was lower after G15 than P10 (P =.007), whereas time spent with glucose more than 5.5 mmol/L, peak glucose and insulin 15 minutes postcorrection were higher after G15 than G5 and P10 (P <.001). Glucagon 15 minutes postcorrection was higher after P10 than after G15 and G5 (P =.002 and P =.003, respectively). G15 resulted in rebound hypoglycaemia (< 3.0 mmol/L) in three of eight cases (38%), while no rebound hypoglycaemia occurred with G5 and P10. Conclusions: Correcting hypoglycaemia with 15 g of glucose should be reconsidered in post‐RYGB PBH. A lower dose appears to sufficiently increase glucose levels outside the critical range in most cases, and complementary nutrients (e.g. proteins) may provide glycaemia‐stabilizing benefits. Registration number of clinical trial: NTC05250271 (ClinicalTrials.gov). [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
