دورية أكاديمية
Sleep Apnea is Associated With Accelerated Vascular Aging: Results From 2 European Community‐Based Cohort Studies
| العنوان: | Sleep Apnea is Associated With Accelerated Vascular Aging: Results From 2 European Community‐Based Cohort Studies |
|---|---|
| المؤلفون: | Lisan, Quentin, van Sloten, Thomas, Boutouyrie, Pierre, Laurent, Stéphane, Danchin, Nicolas, Thomas, Frédérique, Guibout, Catherine, Perier, Marie‐cécile, Dagnelie, Pieter, Henry, Ronald, Schram, Miranda, Heinzer, Raphaël, Marques-Vidal, Pedro, van der Kallen, Carla, Crijns, Harry, van Greevenbroek, Marleen, Reesink, Koen, Köhler, Sebastian, Sastry, Manuel, Jouven, Xavier, Stehouwer, Coen, Empana, Jean‐philippe |
| المساهمون: | Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou APHP (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), ANR-17-CE36-0012,EPICARSLEEP,Epidemiologie des troubles du sommeil et des maladies cardiovasculaires en population(2017) |
| المصدر: | ISSN: 2047-9980 ; Journal of the American Heart Association ; https://hal.science/hal-04243952Test ; Journal of the American Heart Association, 2021, 10 (15), ⟨10.1161/JAHA.120.021318⟩. |
| بيانات النشر: | HAL CCSD Wiley-Blackwell |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | Background The mechanisms underlying the association between obstructive sleep apnea (OSA) and cardiovascular disease may include accelerated vascular aging. The aim was to compare the magnitude of vascular aging in patients with high versus low risk of OSA. Methods and Results In 2 community‐based studies, the PPS3 (Paris Prospective Study 3) and the Maastricht Study, high risk of OSA was determined with the Berlin questionnaire (a screening questionnaire for OSA). We assessed carotid artery properties (carotid intima‐media thickness, Young’s elastic modulus, carotid‐femoral pulse wave velocity, carotid pulse wave velocity, carotid diameter using high precision ultrasound echography), and carotid‐femoral pulse wave velocity (in the Maastricht Study only). Regression coefficients were estimated on pooled data using multivariate linear regression. A total of 8615 participants without prior cardiovascular disease were included (6840 from PPS3, 62% men, mean age 59.5±6.2 years, and 1775 from the Maastricht Study, 51% men, 58.9±8.1 years). Overall, high risk of OSA prevalence was 16.8% (n=1150) in PPS3 and 23.8% (n=423) in the Maastricht Study. A high risk of OSA was associated with greater carotid intima‐media thickness (β=0.21; 0.17–0.26), Young’s elastic modulus (β=0.21; 0.17–0.25), carotid‐femoral pulse wave velocity (β=0.24; 0.14–0.34), carotid pulse wave velocity (β=0.31; 0.26–0.35), and carotid diameter (β=0.43; 0.38–0.48), after adjustment for age, sex, total cholesterol, smoking, education level, diabetes mellitus, heart rate, and study site. Consistent associations were observed after additional adjustments for mean blood pressure, body mass index, or antihypertensive medications. Conclusions These data lend support for accelerated vascular aging in individuals with high risk of OSA. This may, at least in part, underlie the association between OSA and cardiovascular disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | hal-04243952; https://hal.science/hal-04243952Test |
| DOI: | 10.1161/JAHA.120.021318 |
| الإتاحة: | https://doi.org/10.1161/JAHA.120.021318Test https://hal.science/hal-04243952Test |
| رقم الانضمام: | edsbas.A806E272 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1161/JAHA.120.021318 |
|---|