التفاصيل البيبلوغرافية
| العنوان: |
TNF receptors 1 and 2 exert distinct region-specific effects on striatal and hippocampal grey matter volumes ( VBM) in healthy adults. |
| المؤلفون: |
Stacey, D., Redlich, R., Büschel, A., Opel, N., Grotegerd, D., Zaremba, D., Dohm, K., Bürger, C., Meinert, S. L., Förster, K., Repple, J., Kaufmann, C., Kugel, H., Heindel, W., Arolt, V., Dannlowski, U., Baune, B. T. |
| المصدر: |
Genes, Brain & Behavior; Mar2017, Vol. 16 Issue 3, p352-360, 9p |
| مصطلحات موضوعية: |
NEUROBEHAVIORAL disorders, TUMOR necrosis factor receptors, PATHOLOGICAL physiology, NEURODEGENERATION, BRAIN imaging, HIPPOCAMPUS physiology |
| مستخلص: |
Tumour necrosis factor alpha ( TNFα) has been implicated in the pathophysiology of neurodegenerative and neuropsychiatric disease, with research highlighting a role for TNFα in hippocampal and striatal regulation. TNFα signals are primarily transduced by TNF receptors 1 and 2 ( TNFR1 and TNFR2), encoded by TNFRSF1A and TNFRSF1B, which exert opposing effects on cell survival ( TNFR1, neurodegenerative; TNFR2, neuroprotective). We therefore sought to explore the respective roles of TNFR1 and TNFR2 in the regulation of hippocampal and striatal morphology in an imaging genetics study. Voxel-based morphometry was used to analyse the associations between TNFRSF1A (rs4149576 and rs4149577) and TNFRSF1B (rs1061624) genotypes and grey matter structure. The final samples comprised a total of 505 subjects (mean age = 33.29, SD = 11.55 years; 285 females and 220 males) for morphometric analyses of rs1061624 and rs4149576, and 493 subjects for rs4149577 (mean age = 33.20, SD = 11.56 years; 281 females and 212 males). Analyses of TNFRSF1A single nucleotide polymorphisms ( SNPs) rs4149576 and rs4149577 showed highly significant genotypic associations with striatal volume but not the hippocampus. Specifically, for rs4149576, G homozygotes were associated with reduced caudate nucleus volumes relative to A homozygotes and heterozygotes, whereas for rs4149577, reduced caudate volumes were observed in C homozygotes relative to T homozygotes and heterozygotes. Analysis of the TNFRSF1B SNP rs1061624 yielded a significant association with hippocampal but not with striatal volume, whereby G homozygotes were associated with increased volumes relative to A homozygotes and heterozygotes. Our findings indicate a role for TNFR1 in regulating striatal but not hippocampal morphology, as well as a complementary role for TNFR2 in hippocampal but not in striatal morphology. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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