التفاصيل البيبلوغرافية
| العنوان: |
Induction of protective and therapeutic antitumor immunity by a DNA vaccine with a glioma antigen, SOX6. |
| المؤلفون: |
Ueda, Ryo, Kinoshita, Eiko, Ito, Rena, Kawase, Takeshi, Kawakami, Yutaka, Toda, Masahiro |
| المصدر: |
International Journal of Cancer; May2008, Vol. 122 Issue 10, p2274-2279, 6p |
| مستخلص: |
We previously reported identifying SOX6 as a glioma antigen by serological screening using a testis cDNA library. Its preferential expression and frequent IgG responses in glioma patients indicate that SOX6 may be a useful target for immunotherapy. To examine whether cytotoxic T-lymphocyte (CTL) responses specific for SOX6 to destroy glioma can be generated in vivo, we treated glioma-bearing mice by vaccination with a plasmid DNA encoding murine full-length SOX6 protein. Following SOX6-DNA vaccination, CTLs specific for SOX6-expressing glioma cells were induced, while normal autologous-cells that had restrictedly expressed SOX6 during embryogenesis were not destroyed. Furthermore, DNA vaccination with SOX6 exerted protective and therapeutic antitumor responses in the glioma-bearing mice. This antitumor activity was abrogated by the depletion of CD4 positive T cells and/or CD8 positive T cells. These results suggest that the SOX6 protein has multiple CTL and helper epitopes to induce antitumor activity and the effectiveness of SOX6-DNA vaccine for the prevention and treatment of glioma. © 2008 Wiley-Liss, Inc. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
