المؤلفون: Eydoux, Raphaëlle, Castinetti, Frédéric, Authier, Magali, Vialle, Manon, Albarel, Frédérique, Brue, Thierry, Courbiere, Blandine

المصدر: Clinical Endocrinology; May2021, Vol. 94 Issue 5, p880-887, 8p

مصطلحات موضوعية: FEMININITY, CRANIOPHARYNGIOMA, QUALITY of life, QUALITATIVE research, CHILDBEARING age, HYSTEROSALPINGOGRAPHY

مستخلص: Background: Previous quantitative studies have shown a reduced quality of life in patients treated for craniopharyngioma (CP). However, few have assessed their sexual quality of life and other issues related to patient intimacy have not yet been addressed. Standardized questionnaires limit the approach to sexuality and the exploration of patient experiences. A qualitative study, which allows in‐depth analysis, may represent an interesting approach to explore intimacy in women with a history of CP. Objective: To assess the impact of a CP history on femininity and relationships in women. Design and patients: A qualitative study with semi‐structured interviews was conducted with 15 adult women treated for CP during childhood, adolescence or at childbearing age up to 40 years of age. Interviews were audio recorded, anonymized and transcribed literally. Data analysis was carried out with an inductive approach according to the grounded theory method. Results: Three main themes were identified: (a) apparent changes leading to altered self‐perception that may impact on femininity and generate lower self‐esteem; (b) managing the hidden disabilities of the disease inducing a need for permanent control; and (c) building parenthood and couple relationships: coping with sexual dysfunction and infertility. Conclusions: Our study highlighted alterations in self‐perception and femininity due to body change and disability resulting from CP treatment, impacting both couple and social relationships. Interviewing women who underwent CP surgery at different ages highlighted specific needs and different expectations of medical professionals which emphasize the importance of offering both global and personalized care. [ABSTRACT FROM AUTHOR]

: Copyright of Clinical Endocrinology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Vergier, Julia, Bottin, Pauline, Saias, Jacqueline, Reynaud, Rachel, Guillemain, Catherine, Courbiere, Blandine

المصدر: Clinical Endocrinology; Nov2019, Vol. 91 Issue 5, p646-651, 6p, 3 Charts

مصطلحات موضوعية: FERTILITY preservation, TURNER'S syndrome, PREMATURE ovarian failure, OVARIAN reserve, GONADAL dysgenesis, FERTILIZATION in vitro, FROZEN human embryos

مستخلص: Objective: Turner syndrome (TS) is responsible for gonadal dysgenesis with high risk of premature ovarian insufficiency. Little is known about fertility preservation (FP) strategies is this population. Design: Data from women with TS consulting with a fertility specialist in our FP centre from 2014 to 2018 were retrospectively collected. Measurement: Total number of mature oocytes cryopreserved using vitrification. Patients: Nine women with TS were referred. Three women with different karyotypes underwent controlled ovarian stimulation (COS) for oocyte vitrification. Mean age at TS diagnosis was 13.7 years [9‐20]. Mean referral delay between TS diagnosis and fertility consultation was 9.7 years [7‐14]. First counselling for FP was provided at 23.7 years [18‐28]. Mean AMH serum level prior to COS was 53.8 pmol/L [3.6‐95]. Results: All three women succeeded in obtaining cryopreserved oocytes with a mean number of 15.3 per woman [9‐20] and 9.2 per COS cycle [2‐20]. Ovarian response to COS was unexpectedly remarkable for the woman with a complete 45,X monosomy. Procedure was well tolerated for all women. None of them have used oocytes for in vitro fertilization yet. Conclusions: Independently of karyotype, antral follicular count, AMH and FSH levels seemed to be reliable predictive markers of oocyte cryopreservation success. In a monosomic TS woman, cryptic ovarian mosaicism could explain a successful ovarian response to stimulation with a high number of retrieved oocytes. In case of spontaneous menarche, TS adolescents should be referred during transition to adulthood for FP counselling to avoid referral delay and limit time‐related diminished ovarian reserve. [ABSTRACT FROM AUTHOR]

: Copyright of Clinical Endocrinology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Provansal, Magali¹, Courbiere, Blandine¹, Agostini, Aubert¹, D'Ercole, Claude², Boubli, Léon², Bretelle, Florence^2,3 florence.bretelle@ap-hm.fr, Boubli, Léon (AUTHOR)

المصدر: International Journal of Gynecology & Obstetrics. May2010, Vol. 109 Issue 2, p147-150. 4p.

مصطلحات موضوعية: *HUMAN fertility, *OBSTETRICS, *PLACENTA diseases, *HYSTERECTOMY, *MENSTRUAL cycle, *AMENORRHEA, *PREGNANCY, *ACADEMIC medical centers, *CESAREAN section, *FERTILITY, *INFERTILITY, *LABOR complications (Obstetrics), *LONGITUDINAL method, *MENSTRUATION, *TREATMENT effectiveness, *RETROSPECTIVE studies, *THERAPEUTICS, *PREVENTION

مصطلحات جغرافية: FRANCE

مستخلص: Objective: To determine the fertility and obstetric outcomes after conservative management of placenta accreta.Methods: A retrospective observational cohort study of all identified cases of placenta accreta from 1993 to 2007 in 2 tertiary university hospitals in France. For patients treated conservatively, maternal and fetal morbidity, reproductive function, fertility, and subsequent pregnancies were recorded.Results: During the study period, 46 patients were treated by conservative management; 6 patients underwent a secondary hysterectomy. Of the remaining 40 patients, 35 were followed up for a median of 65 months (range 18-156 months). Patients resumed their menstrual cycles after a median of 130 days (range 48-176 days). Menses were irregular in 11 patients (31%), but none had amenorrhea. Twelve of the 14 patients desiring another pregnancy achieved a total of 15 pregnancies; 2 patients had recurrent placenta accreta. Five spontaneous abortions and 1 termination of pregnancy occurred during the first trimester. The median term at delivery was 37 weeks (range, 35-40 weeks). Four patients delivered prematurely.Conclusion: Conservative management of placenta accreta can preserve fertility, although the risk of recurrent placenta accreta appears to be high. [ABSTRACT FROM AUTHOR]