التفاصيل البيبلوغرافية
| العنوان: |
Pathological features of Prostate Imaging Reporting and Data System (PI‐RADS) 3 MRI lesions in biopsy and radical prostatectomy specimens. |
| المؤلفون: |
Rahota, Razvan‐George1 (AUTHOR) drrazvanrahota@gmail.com, Diamand, Romain2 (AUTHOR), Malavaud, Bernard3,4 (AUTHOR), Fiard, Gaëlle5 (AUTHOR), Descotes, Jean‐Luc5 (AUTHOR), Peltier, Alexandre6 (AUTHOR), Beauval, Jean‐Baptiste1 (AUTHOR), Roumeguère, Thierry2 (AUTHOR), Roumiguié, Mathieu3 (AUTHOR), Albisinni, Simone2 (AUTHOR), Ploussard, Guillaume1 (AUTHOR) |
| المصدر: |
BJU International. May2022, Vol. 129 Issue 5, p621-626. 6p. |
| مصطلحات موضوعية: |
*PROSTATE cancer, *RADICAL prostatectomy, *MAGNETIC resonance imaging, *BIOPSY, *PROSTATE, *PROSTATE-specific antigen |
| مستخلص: |
Objective: To assess the whole pathology spectrum of Prostate Imaging Reporting and Data System (PI‐RADS) 3 lesions, identified on magnetic resonance imaging, using systematic (SB), targeted biopsy (TB) and radical prostatectomy (RP) specimen analysis. Methods: From a prospective database of patients undergoing RP after a combination of SB (median 12 cores) and fusion TB (median 3 cores), we included 150 PI‐RADS 3 cases. Clinically significant prostate cancer (csPCa) was defined by a Grade Group 2 or more. The primary endpoints were unfavourable features in RP specimens. Results: Targeted biopsy was negative in 20.7% of patients. Final Grade Group 3 or more and a pT3 stage was reported in 36.7% and 38.7% of RP specimens. The upgrading rate was 38.2% between biopsy and RP specimens. The concordance rate between Grade Group on TB and RP was only 38.0%. The two independent predictive factors for unfavourable disease (pT3–4 and/or final Grade Group 3–5) were prostate‐specific antigen density (PSAD; P = 0.001) and presence of csPCa on TB (odds ratio 3.7; P = 0.001). The risk of unfavourable disease was increased 2.3‐fold and 5.8‐fold, respectively, for patients with a PSAD between 0.15 and 0.20, and a PSAD >0.20 ng/mL/g. The 5‐year biochemical recurrence‐free survival rate was 93.2%. Conclusions: PI‐RADS 3 lesions exhibited aggressive features in almost 40% of cases. PSAD and presence of csPCa on TB are independent predictive factors for high‐grade and/or extraprostatic disease. A combination of SB and TB improve grade prediction compared to use of TB alone. [ABSTRACT FROM AUTHOR] |
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