التفاصيل البيبلوغرافية
| العنوان: |
Faster insulin action is associated with improved glycaemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy in adults with type 1 diabetes. |
| المؤلفون: |
Ruan, Yue, Thabit, Hood, Leelarathna, Lalantha, Hartnell, Sara, Wilinska, Malgorzata E., Tauschmann, Martin, Dellweg, Sibylle, Benesch, Carsten, Mader, Julia K., Holzer, Manuel, Kojzar, Harald, Evans, Mark L., Pieber, Thomas R., Arnolds, Sabine, Hovorka, Roman |
| المصدر: |
Diabetes, Obesity & Metabolism; Oct2017, Vol. 19 Issue 10, p1485-1489, 1p |
| مصطلحات موضوعية: |
PHARMACODYNAMICS, GLYCEMIC control, INSULIN pumps, TYPE 1 diabetes, BODY mass index |
| مستخلص: |
We aimed to evaluate the relationship between insulin pharmacodynamics and glycaemic outcomes during closed-loop insulin delivery and sensor-augmented pump therapy. We retrospectively analysed data from a multicentre randomized control trial involving 32 adults with type 1 diabetes receiving day-and-night closed-loop insulin delivery and sensor-augmented pump therapy over 12 weeks. We estimated time-to-peak insulin action ( tmax, IA ) and insulin sensitivity ( S I ) during both interventions, and correlated these with demographic factors and glycaemic outcomes. During both interventions, tmax, IA was positively correlated with pre- and post-intervention HbA1c ( r = 0.50-0.52, P < .01) and mean glucose ( r = 0.45-0.62, P < .05), and inversely correlated with time sensor glucose, which was in target range 3.9 to 10 mmol/L ( r = −0.64 to −0.47, P < .05). Increased body mass index was associated with higher tmax, I and lower S I (both P < .05). During closed-loop insulin delivery, tmax, IA was positively correlated with glucose variability ( P < .05). Faster insulin action is associated with improved glycaemic control during closed-loop insulin delivery and sensor-augmented pump therapy. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
