التفاصيل البيبلوغرافية
| العنوان: |
Basal cell carcinoma is associated with high TNF-α release but not with TNF-α polymorphism at position − 308. |
| المؤلفون: |
Skov, Lone, Allen, Michael H., Bang, Bo, Francis, David, Barker, Jonathan N.W.N., Baadsgaard, Ole |
| المصدر: |
Experimental Dermatology; Dec2003, Vol. 12 Issue 6, p772-776, 5p |
| مصطلحات موضوعية: |
BASAL cell carcinoma, TUMOR necrosis factors, ULTRAVIOLET radiation, GENETIC polymorphisms, SKIN cancer, GROWTH factors |
| مستخلص: |
Skov L, Allen MH, Bang B, Francis D, Barker JNWN, Baadsgaard O. Basal cell carcinoma is associated with high TNF-α release but not with TNF-α polymorphism at position − 308. The mechanisms underlying induction of UVB-induced immunosuppression are not fully understood, but tumour necrosis factor alpha (TNF-α) is suggested to play a central role. A single base pair polymorphism at position − 308 in the promoter region of the TNF-α gene associated with an enhanced secretion of TNF-α has been identified in humans. We have therefore investigated the association of the − 308 polymorphism with the risk of basal cell carcinoma (BCC) in humans. The frequency of TNF G and TNF A alleles among Caucasian patients with a previous BCC ( n= 191) and healthy adults ( n= 107) were compared. For the TNF − 308 polymorphism there was no significant association between the genotype or allele frequencies and having a BCC. To determine whether patients with a previous BCC had an increased capacity to secrete TNF-α, mononuclear cells were stimulated with lipopolysaccharide. Mononuclear cells from patients with a previous BCC ( n= 15) demonstrated a significantly increased release of TNF-α upon stimulation with lipopolysaccharide ( P < 0.03) compared with mononuclear cells from age-matched control subjects ( n= 16). Further studies of other polymorphisms of the TNF-α gene associated with increased TNF-α production and BCC are necessary. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
