دورية أكاديمية
Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: A replication study
| العنوان: | Contribution of LPHN3 to the genetic susceptibility to ADHD in adulthood: A replication study |
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| المؤلفون: | Ribases, M., Ramos-Quiroga, J. A., Sanchez-Mora, C., Bosch, R., Richarte, V., Palomar, G., Gastaminza, X., Biesla, A., Muenke, Maximilian, Arcos-Burgos, Mauricio, Castellanos, Francisco Xavier |
| المصدر: | Genes, Brain and Behavior |
| بيانات النشر: | Wiley-Blackwell |
| المجموعة: | Australian National University: ANU Digital Collections |
| مصطلحات موضوعية: | Keywords: G protein coupled receptor, latrophilin 3, unclassified drug, adult, amygdaloid nucleus, article, attention deficit disorder, brain cortex, case control study, caudate nucleus, cerebellum, Colombia, controlled study, developmental disorder, female, gene i Adult ADHD, Attention-deficit/hyperactivity disorder, Case-control association study, LPHN3 |
| الوصف: | Attention-deficit/hyperactivity disorder (ADHD) is a common and highly heritable developmental disorder characterized by a persistent impairing pattern of inattention and/or hyperactivity-impulsivity. Using families from a genetic isolate, the Paisa population from Colombia, and five independent datasets from four different populations (United States, Germany, Norway and Spain), a highly consistent association was recently reported between ADHD and the latrophilin 3 (LPHN3) gene, a brain-specific member of the LPHN subfamily of G-protein-coupled receptors that is expressed in ADHD-related regions, such as amygdala, caudate nucleus, cerebellum and cerebral cortex. To replicate the association between LPHN3 and ADHD in adults, we undertook a case-control association study in 334 adult patients with ADHD and 334 controls with 43 single nucleotide polymorphisms (SNPs) covering the LPNH3 gene. Single- and multiple-marker analyses showed additional evidence of association between LPHN3 and combined type ADHD in adulthood [P = 0.0019; df = 1; odds ratio (OR) = 1.82 (1.25-2.70) and P = 5.1e-05; df = 1; OR = 2.25 (1.52-3.34), respectively]. These results further support the LPHN3 contribution to combined type ADHD, and specifically to the persistent form of the disorder, and point at this new neuronal pathway as a common susceptibility factor for ADHD throughout the lifespan. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1601-1848 |
| العلاقة: | http://hdl.handle.net/1885/78498Test; https://openresearch-repository.anu.edu.au/bitstream/1885/78498/7/01_Ribases_Contribution_of_LPHN3_to_the_2011.pdf.jpgTest |
| DOI: | 10.1111/j.1601-183X.2010.00649.x |
| الإتاحة: | https://doi.org/10.1111/j.1601-183X.2010.00649.xTest http://hdl.handle.net/1885/78498Test https://openresearch-repository.anu.edu.au/bitstream/1885/78498/7/01_Ribases_Contribution_of_LPHN3_to_the_2011.pdf.jpgTest |
| رقم الانضمام: | edsbas.E0C1D3E3 |
| قاعدة البيانات: | BASE |
| تدمد: | 16011848 |
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| DOI: | 10.1111/j.1601-183X.2010.00649.x |