التفاصيل البيبلوغرافية
| العنوان: |
Higher rate of central nervous system involvement by flow cytometry than morphology in acute lymphoblastic leukemia. |
| المؤلفون: |
Dass, J., Dayama, A., Mishra, P. C., Mahapatra, M., Seth, T., Tyagi, S., Pati, H. P., Saxena, R. |
| المصدر: |
International Journal of Laboratory Hematology; Oct2017, Vol. 39 Issue 5, p546-551, 6p |
| مصطلحات موضوعية: |
CEREBROSPINAL fluid examination, CENTRAL nervous system diseases, CYTOLOGY, FISHER exact test, FLOW cytometry, LACTATE dehydrogenase, LONGITUDINAL method, LYMPHOBLASTIC leukemia, PROBABILITY theory, RECEIVER operating characteristic curves, DATA analysis software, MANN Whitney U Test, DIAGNOSIS, DISEASE risk factors |
| مستخلص: |
Introduction Central nervous system ( CNS) involvement in acute lymphoblastic leukemia ( ALL) is diagnosed traditionally by cytopathology ( CP) of the cerebrospinal fluid ( CSF). Role of flow cytometry ( FC) to diagnose CNS involvement has not been extensively investigated. Methods We aimed to detect CNS involvement in 42 ALL patients (33 B- ALL, nine T- ALL) at diagnosis by FC and comparing it with CP and to correlate it with known risk factors for CNS disease like Lactate dehydrogenase ( LDH). A receiver operating characteristic curve was used to determine the cutoff of LDH to predict CSF involvement. For the analysis of categorical/quantitative variables, Fisher's exact test was used. For the analysis of continuous variables, Mann-Whitney test was used. A P value of <.05 was taken as significant. Results CP and FC were positive in five (11.9%) and 11 patients (26.14%) respectively with FC detecting a significantly higher level of involvement ( P=.001). All CP-positive cases were FC positive. A LDH value of >472 U/L had a sensitivity of 61% and specificity of 62.5% for diagnosis of CSF involvement by FC. Conclusions CSF FC detects CNS disease in ALL patients at diagnosis at a rate double than CP alone and is statistically associated with an elevated LDH level. It should be incorporated in the evaluation of CSF to detect CNS involvement. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
