دورية أكاديمية
Sex-specific aging in animals: Perspective and future directions
| العنوان: | Sex-specific aging in animals: Perspective and future directions |
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| المؤلفون: | Bronikowski, Anne M., Meisel, Richard P., Biga, Peggy R., Walters, James R., Mank, Judith E., Larschan, Erica, Wilkinson, Gerald S., Valenzuela, Nicole, Conard, Ashley Mae, de Magalhães, João Pedro, Duan, Jingyue (Ellie), Elias, Amy E., Gamble, Tony, Graze, Rita M., Gribble, Kristin E., Kreiling, Jill A., Riddle, Nicole C. |
| بيانات النشر: | Wiley Open Access |
| سنة النشر: | 2022 |
| المجموعة: | The University of Kansas: KU ScholarWorks |
| مصطلحات موضوعية: | Aging, Comparative biology, Lifespan, Mortality, Sex differences |
| الوصف: | Sex differences in aging occur in many animal species, and they include sex differences in lifespan, in the onset and progression of age‐associated decline, and in physiological and molecular markers of aging. Sex differences in aging vary greatly across the animal kingdom. For example, there are species with longer‐lived females, species where males live longer, and species lacking sex differences in lifespan. The underlying causes of sex differences in aging remain mostly unknown. Currently, we do not understand the molecular drivers of sex differences in aging, or whether they are related to the accepted hallmarks or pillars of aging or linked to other well‐characterized processes. In particular, understanding the role of sex‐determination mechanisms and sex differences in aging is relatively understudied. Here, we take a comparative, interdisciplinary approach to explore various hypotheses about how sex differences in aging arise. We discuss genomic, morphological, and environmental differences between the sexes and how these relate to sex differences in aging. Finally, we present some suggestions for future research in this area and provide recommendations for promising experimental designs. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | Bronikowski, A. M., Meisel, R. P., Biga, P. R., Walters, J. R., Mank, J. E., Larschan, E., Wilkinson, G. S., Valenzuela, N., Conard, A. M., de Magalhães, J. P., Duan, J. E., Elias, A. E., Gamble, T., Graze, R. M., Gribble, K. E., Kreiling, J. A., & Riddle, N. C. (2022). Sex-specific aging in animals: Perspective and future directions. Aging cell, 21(2), e13542. https://doi.org/10.1111/acel.13542Test; http://hdl.handle.net/1808/32745Test; https://orcid.orgTest/ 0000-0001-6432-298X; https://orcid.orgTest/ 0000-0002-7362-9307; https://orcid.orgTest/ 0000-0002-0540-291X; https://orcid.orgTest/ 0000-0002-6340-995X; https://orcid.orgTest/ 0000-0002-2450-513X; https://orcid.orgTest/ 0000-0003-2484-4921; https://orcid.orgTest/ 0000-0001-7799-8444; https://orcid.orgTest/ 0000-0003-1148-631X; https://orcid.orgTest/ 0000-0002-4143-6180; https://orcid.orgTest/ 0000-0002-6363-2465; https://orcid.orgTest/ 0000-0001-6416-2250; https://orcid.orgTest/ 0000-0001-9013-6240; https://orcid.orgTest/ 0000-0002-0204-8003; https://orcid.orgTest/ 0000-0001-9872-109X; https://orcid.orgTest/ 0000-0002-8781-9523; https://orcid.orgTest/ 0000-0003-4440-2039; https://orcid.orgTest/ 0000-0003-1827-9145; PMC8844111 |
| DOI: | 10.1111/acel.13542 |
| الإتاحة: | https://doi.org/10.1111/acel.13542Test http://hdl.handle.net/1808/32745Test https://orcid.orgTest/ 0000-0001-6432-298X https://orcid.orgTest/ 0000-0002-7362-9307 https://orcid.orgTest/ 0000-0002-0540-291X https://orcid.orgTest/ 0000-0002-6340-995X https://orcid.orgTest/ 0000-0002-2450-513X https://orcid.orgTest/ 0000-0003-2484-4921 https://orcid.orgTest/ 0000-0001-7799-8444 https://orcid.orgTest/ 0000-0003-1148-631X |
| حقوق: | © 2022 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License. ; http://creativecommons.org/licenses/by/4.0Test/ ; openAccess |
| رقم الانضمام: | edsbas.246C7E5D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/acel.13542 |
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