دورية أكاديمية
Comparison of outcomes of different biopsy schedules among men on active surveillance for prostate cancer: An analysis of the G.A.P.3 global consortium database
| العنوان: | Comparison of outcomes of different biopsy schedules among men on active surveillance for prostate cancer: An analysis of the G.A.P.3 global consortium database |
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| المؤلفون: | Beckmann K. R., Bangma C. H., Helleman J., Bjartell A., Carroll P. R., Morgan T., Nieboer D., Santaolalla A., Trock B. J., Valdagni R., Roobol M. J. |
| المساهمون: | K.R. Beckmann, C.H. Bangma, J. Helleman, A. Bjartell, P.R. Carroll, T. Morgan, D. Nieboer, A. Santaolalla, B.J. Trock, R. Valdagni, M.J. Roobol |
| بيانات النشر: | Wiley Blackwell Publishing |
| سنة النشر: | 2022 |
| المجموعة: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| مصطلحات موضوعية: | active surveillance, biopsy schedule, prostate cancer, treatment, upgrading, Settore MED/36 - Diagnostica per Immagini e Radioterapia |
| الوصف: | Background: The optimal interval for repeat biopsy during active surveillance (AS) for prostate cancer is yet to be defined. This study examined whether risk of upgrading (to grade group ≥ 2) or risk of converting to treatment varied according to intensity of repeat biopsy using data from the GAP3 consortium's global AS database. Materials and Methods: Intensity of surveillance biopsy schedules was categorized according to centers’ protocols: (a) Prostate Cancer Research International Active Surveillance project (PRIAS) protocols with biopsies at years 1, 4, and 7 (10 centers; 7532 men); (b) biennial biopsies, that is, every other year (8 centers; 4365 men); and (c) annual biopsy schedules (4 centers; 1602 men). Multivariable Cox regression was used to compare outcomes according to biopsy intensity. Results: Out of the 13,508 eligible participants, 56% were managed according to PRIAS protocols (biopsies at years 1, 4, and 7), 32% via biennial biopsy, and 12% via annual biopsy. After adjusting for baseline characteristics, risk of converting to treatment was greater for those on annual compared with PRIAS biopsy schedules (hazard ratio [HR] = 1.66; 95% confidence interval [CI] = 1.51–1.83; p < 0.001), while risk of upgrading did not differ (HR = 0.96; 95% CI = 0.84–1.10). Conclusion: Results suggest more frequent biopsy schedules may deter some men from continuing AS despite no evidence of grade progression. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35254666; info:eu-repo/semantics/altIdentifier/wos/WOS:000765426800001; volume:82; issue:7; firstpage:876; lastpage:879; numberofpages:4; journal:THE PROSTATE; http://hdl.handle.net/2434/917006Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85126054260 |
| DOI: | 10.1002/pros.24330 |
| الإتاحة: | https://doi.org/10.1002/pros.24330Test http://hdl.handle.net/2434/917006Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7B694088 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/pros.24330 |
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