Neoadjuvant chemotherapy for high-grade central osteosarcoma of the extremity
| العنوان: | Neoadjuvant chemotherapy for high-grade central osteosarcoma of the extremity |
|---|---|
| المؤلفون: | Marco Manfrini, Davide Donati, Stefano Lari, R N Cristiana Forni, Roberto Biagini, Patrizia Bacchini, Franco Bertoni, Gaetano Bacci, Gabriella Bernini, Alessandra Longhi, Stefano Ferrari |
| المساهمون: | Bacci G., Bertoni F., Longhi A., Ferrari S., Forni C., Biagini R., Bacchini P., Donati D., Manfrini M., Bernini G., Lari S. |
| المصدر: | Cancer. 97:3068-3075 |
| بيانات النشر: | Wiley, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Male, Cancer Research, medicine.medical_specialty, Pathology, Adolescent, Prognosi, medicine.medical_treatment, Preoperative care, Gastroenterology, Internal medicine, Response to chemotherapy, Preoperative Care, medicine, Humans, Antineoplastic Protocol, Neoadjuvant therapy, Survival analysis, Osteosarcoma, Chemotherapy, business.industry, Antineoplastic Protocols, Cancer, Extremities, Prognosis, medicine.disease, Survival Analysis, Neoadjuvant Therapy, Oncology, Chemotherapy, Adjuvant, Localized disease, Female, Histopathology, Survival Analysi, Histologic subtype, business, Human |
| الوصف: | BACKGROUND In primary central high-grade osteosarcoma, a number of distinct subtypes have been identified, but little is known about the response to chemotherapy. METHODS The authors investigated whether the subtypes correlated with histologic response to chemotherapy in 1058 patients with osteosarcoma of the extremities who were treated with neoadjuvant chemotherapy over the last 20 years. The tumors were classified as osteoblastic (70%), chondroblastic (13%), fibroblastic (9%), and telangiectatic (6%). At diagnosis, 911 patients had localized disease and 147 had resectable lung metastases. RESULTS The response to preoperative chemotherapy was good (90% or more tumor necrosis) in 59% of patients and poor (< 90% tumor necrosis) in 41% of patients. The rate of good responses was significantly higher (P = 0.0001) in the fibroblastic (83%) and telangiectatic (80%) tumors and significantly lower in chondroblastic tumors (43%). Prognosis was significantly correlated with the histologic subtypes. The 5-year overall survival rate was significantly higher (P = 0.0001) in fibroblastic (83%) and telangiectatic (75%) tumors than in osteoblastic (62%) and chondroblastic (60%) tumors. In all subtypes, except for the chondroblastic subtype, the 5-year overall survival rate was significantly higher (P = 0.0001) in good responders P = 0.0001 (68%) than in poor responders (52%). CONCLUSIONS The authors concluded that the histologic subtype of primary central high-grade osteosarcoma of the extremity was strictly correlated with histologic response to chemotherapy and probably, as a consequence, also with prognosis. Further studies are needed to establish whether these results justify a specific therapeutic approach based on the histologic subtype of the tumor. Cancer 2003;97:3068–75. © 2003 American Cancer Society. DOI 10.1002/cncr.11456 |
| وصف الملف: | STAMPA |
| تدمد: | 1097-0142 0008-543X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c15fc040be7cd49569faecbe507d4a3dTest https://doi.org/10.1002/cncr.11456Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c15fc040be7cd49569faecbe507d4a3d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10970142 0008543X |
|---|