التفاصيل البيبلوغرافية
| العنوان: |
Persistence of antibodies 5 years after hepatitis B vaccination in preterm birth children: A retrospective cohort study using real‐world data |
| المؤلفون: |
Qin, Wei, Shao, Ling, Wang, Jun, Zhang, Huan, Wang, Yao, Zhang, Xiaqing, Xie, Shaoyu, Pan, Fan, Cheng, Kai, Ma, Liguo, Chen, Yafei, Song, Jian, Gao, Dawei, Chen, Zhichao, Yang, Wei, Zhu, Rui, Su, Hong |
| المصدر: |
Journal of Viral Hepatitis ; volume 31, issue 3, page 143-150 ; ISSN 1352-0504 1365-2893 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2024 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Previous studies did not provide substantial evidence for long‐term immune persistence after the hepatitis B vaccine (HepB) in preterm birth (PTB) children. Consequently, there is ongoing controversy surrounding the booster immunization strategy for these children. Therefore, we conducted a retrospective cohort study to evaluate the disparities in immune persistence between PTB children and full‐term children. A total of 1027 participants were enrolled in this study, including 505 PTB children in the exposure group and 522 full‐term children in the control group. The negative rate of hepatitis B surface antibody (HBsAb) in the PTB group was significantly lower than that in the control group (47.9% vs. 41.4%, p = .035). The risk of HBsAb‐negative in the exposure group was 1.5 times higher than that in the control group (adjusted odds ratio [aOR] = 1.5, 95% confidence interval [CI]: 1.1–2.0). The geometric mean concentration (GMC) of HBsAb was much lower for participants in the exposure group compared to participants in the control group (9.3 vs. 12.4 mIU/mL, p = .029). Subgroup analysis showed that the very preterm infants (gestational age <32 weeks) and the preterm low birth weight infants (birth weight <2000 g) had relatively low GMC levels of 3.2 mIU/mL (95% CI: 0.9–11.1) and 7.9 mIU/mL (95% CI: 4.2–14.8), respectively. Our findings demonstrated that PTB had a significant impact on the long‐term persistence of HBsAb after HepB vaccination. The very preterm infants (gestational age <32 weeks) and the preterm low birth weight infants (birth weight <2000 g) may be special populations that should be given priority for HepB booster vaccination. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/jvh.13908 |
| الإتاحة: |
https://doi.org/10.1111/jvh.13908Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.383A3D8C |
| قاعدة البيانات: |
BASE |
