التفاصيل البيبلوغرافية
| العنوان: |
Selective block of Ca2+-dependent K+current in crayfish neuromuscular system and chromaffin cells by sea anemoneBunodosoma cangicumvenom |
| المؤلفون: |
Luis Gandía, C. Cerveñansky, A. Araque, F. J. Urbano, Washinton Buño |
| المصدر: |
Journal of Neuroscience Research. 42:539-546 |
| بيانات النشر: |
Wiley, 1995. |
| سنة النشر: |
1995 |
| مصطلحات موضوعية: |
Cellular and Molecular Neuroscience, biology, Postsynaptic Current, Excitatory postsynaptic potential, Biophysics, Venom, Sea anemone, Neurotransmission, Nematocyst, biology.organism_classification, Crayfish, Inhibitory postsynaptic potential, Neuroscience |
| الوصف: |
The effects of the nematocyst venom of the sea anemone Bunodosoma cangicum on depolarization-activated currents were studied in opener crayfish muscle fibers and in cultured bovine chromaffin cells. The venom selectively and reversibly blocked the Ca2+ -dependent K+ current (IK(Ca)) present in crayfish muscle in a dose-dependent manner without affecting voltage-gated Ca2+ or K+ currents. Furthermore, the venom also reduced IK(Ca) in chromaffin cells, without modifying voltage-gated Na+, Ca2+, or K+ currents. Synaptic transmission in crayfish muscle was also affected by the venom. Repetitive excitatory and inhibitory postsynaptic currents (each associated with a presynaptic action potential) were evoked by each nerve stimulus, suggesting that presynaptic IK(Ca) may control the electrical activity of excitatory and inhibitory presynaptic fibers. We conclude that B. cangicum venom includes a toxin that selectively and reversibly blocks Ca2+ -dependent K+ currents in crayfish muscle and in bovine chromaffin cells, and modifies excitatory and inhibitory synaptic transmission, probably abolishing a similar conductance at the presynaptic fibers. © 1995 Wiley-Liss, Inc. |
| تدمد: |
0360-4012 |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_________::af5d834a5663bf90c49b1d65acd50946Test
https://doi.org/10.1002/jnr.490420412Test |
| حقوق: |
CLOSED |
| رقم الانضمام: |
edsair.doi...........af5d834a5663bf90c49b1d65acd50946 |
| قاعدة البيانات: |
OpenAIRE |
