التفاصيل البيبلوغرافية
| العنوان: |
Pneumococcal lipoproteins involved in bacterial fitness, virulence, and immune evasion |
| المؤلفون: |
Kohler, Sylvia, Voß, Franziska, Gómez Mejia, Alejandro, Brown, Jeremy S., Hammerschmidt, Sven |
| المساهمون: |
Deutsche Forschungsgemeinschaft, Meningitis Now, National Institute for Health Research |
| المصدر: |
FEBS Letters ; volume 590, issue 21, page 3820-3839 ; ISSN 0014-5793 1873-3468 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2016 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Streptococcus pneumoniae (pneumococcus) has evolved sophisticated strategies to survive in several niches within the human body either as a harmless commensal or as a serious pathogen causing a variety of diseases. The dynamic interaction between pneumococci and resident host cells during colonization of the upper respiratory tract and at the site of infection is critical for bacterial survival and the development of disease. Pneumococcal lipoproteins are peripherally anchored membrane proteins and have pivotal roles in bacterial fitness including envelope stability, cell division, nutrient acquisition, signal transduction, transport (as substrate‐binding proteins of ABC transporter systems), resistance to oxidative stress and antibiotics, and protein folding. In addition, lipoproteins are directly involved in virulence‐associated processes such as adhesion, colonization, and persistence through immune evasion. Conversely, lipoproteins are also targets for the host response both as ligands for toll‐like receptors and as targets for acquired antibodies. This review summarizes the multifaceted roles of selected pneumococcal lipoproteins and how this knowledge can be exploited to combat pneumococcal infections. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/1873-3468.12352 |
| الإتاحة: |
https://doi.org/10.1002/1873-3468.12352Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.1D059375 |
| قاعدة البيانات: |
BASE |
