Evaluation of body composition as a potential biomarker in spinal muscular atrophy
| العنوان: | Evaluation of body composition as a potential biomarker in spinal muscular atrophy |
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| المؤلفون: | Katia Alberti, Alessandro Leone, Chiara Mastella, Giovanni Baranello, Andrea Foppiani, Alberto Battezzati, Simona Bertoli, Maria Teresa Arnoldi, Riccardo Masson, Ramona De Amicis, Riccardo Zanin |
| المصدر: | Muscle & Nerve. 61:530-534 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Physiology, 030105 genetics & heredity, Fat mass, Muscular Atrophy, Spinal, 03 medical and health sciences, Cellular and Molecular Neuroscience, Absorptiometry, Photon, 0302 clinical medicine, Physiology (medical), medicine, Humans, Child, business.industry, Infant, Spinal muscular atrophy, Anthropometry, medicine.disease, SMA, Cross-Sectional Studies, Adipose Tissue, Child, Preschool, Potential biomarkers, Reference values, Body Composition, Physical therapy, Lean body mass, Female, Neurology (clinical), business, Body mass index, Biomarkers, 030217 neurology & neurosurgery |
| الوصف: | INTRODUCTION We aimed to investigate the correlation between body composition (BC) and spinal muscular atrophy (SMA)‐specific motor function assessments. METHODS Patients with SMA types I or II, aged 1 to 10 years, were recruited in this cross‐sectional study. The protocol included anthropometric measurements, and dual‐energy X‐ray absoprtiometry to assess fat mass (FM), lean mass (LM), fat‐free mass (FFM), FM and FFM indexes (FMI, FFMI), and motor function assessments (Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders scale for SMAI, and Hammersmith Functional Motor Scale―Expanded for SMAII). DISCUSSION Eighty‐eight children were included. All had a higher FM percentage than reference values. Motor function was moderately correlated with body mass index (BMI), FFMI, and LMI in SMAI, and weakly correlated with FFMI, LMI, and LM:FM ratio in SMAII. DISCUSSION BC shows promise as a potential biomarker for SMA, but further studies are needed. |
| تدمد: | 1097-4598 0148-639X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8154421ce8a7e03ca07e5511fbc7b63Test https://doi.org/10.1002/mus.26823Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b8154421ce8a7e03ca07e5511fbc7b63 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974598 0148639X |
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