Base Metal Catalyzed Isocyanide Insertions
العنوان: | Base Metal Catalyzed Isocyanide Insertions |
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المؤلفون: | Romano V. A. Orru, Thomas R. Roose, Bert U. W. Maes, Eelco Ruijter, Jurriën W. Collet |
المصدر: | Collet, J W, Roose, T R, Ruijter, E, Maes, B U W & Orru, R V A 2020, ' Base Metal Catalyzed Isocyanide Insertions ', Angewandte Chemie. International Edition, vol. 59, no. 2, pp. 540-558 . https://doi.org/10.1002/anie.201905838Test Angewandte Chemie: international edition in English |
بيانات النشر: | Wiley, 2020. |
سنة النشر: | 2020 |
مصطلحات موضوعية: | 010405 organic chemistry, C building blocks, Isocyanide, General Medicine, General Chemistry, imidoylation, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Chemistry, isocyanides, chemistry.chemical_compound, chemistry, Transition metal, Nucleophile, Electrophile, Functional group, synthetic methods, Moiety, Organometallic chemistry, base metal catalysis |
الوصف: | Isocyanides are diverse C1 building blocks considering their potential to react with nucleophiles, electrophiles, and radicals. Therefore, perhaps not surprisingly, isocyanides are highly valuable as inputs for multicomponent reactions (MCRs) and other one-pot cascade processes. In the field of organometallic chemistry, isocyanides typically serve as ligands for transition metals. The coordination of isocyanides to metal centers alters the electronic distribution of the isocyano moiety, and reaction pathways can therefore be accessed that are not possible in the absence of the metal. The tunable reactivity of the isocyanide functional group by transition metals has evolved into numerous useful applications. Especially palladium-catalyzed isocyanide insertion processes have emerged as powerful reactions in the past decade. However, reports on the use of earth-abundant and cheap base metals in these types of transformations are scarce and have received far less attention. In this Minireview, we focus on these emerging base metal catalyzed reactions and highlight their potential in synthetic organic chemistry. Although mechanistic studies are still scarce, we discuss distinct proposed catalytic cycles and categorize the literature according to 1) the (hetero)atom bound to and 2) the type of bonding with the transition metal in which the (formal) insertion occurs. |
وصف الملف: | application/pdf |
تدمد: | 1521-3773 1433-7851 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30a803eff3405a842d7de1a9d1475417Test https://doi.org/10.1002/anie.201905838Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....30a803eff3405a842d7de1a9d1475417 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 15213773 14337851 |
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