التفاصيل البيبلوغرافية
| العنوان: |
SU‐E‐T‐580: On the Significance of Model Based Dosimetry for Breast and Head and Neck 192Ir HDR Brachytherapy |
| المؤلفون: |
Peppa, V, Pappas, E, Pantelis, E, Major, T, Polgar, C, Papagiannis, P |
| المصدر: |
Medical Physics ; volume 42, issue 6Part21, page 3469-3469 ; ISSN 0094-2405 2473-4209 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2015 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Purpose: To assess the dosimetric and radiobiological differences between TG43‐based and model‐based dosimetry in the treatment planning of 192 Ir HDR brachytherapy for breast and head and neck cancer. Methods: Two cohorts of 57 Accelerated Partial Breast Irradiation (APBI) and 22 head and neck (H&N) patients with oral cavity carcinoma were studied. Dosimetry for the treatment plans was performed using the TG43 algorithm of the Oncentra Brachy v4.4 treatment planning system (TPS). Corresponding Monte Carlo (MC) simulations were performed using MCNP6 with input files automatically prepared by the BrachyGuide software tool from DICOM RT plan data. TG43 and MC data were compared in terms of % dose differences, Dose Volume Histograms (DVHs) and related indices of clinical interest for the Planning Target Volume (PTV) and the Organs‐At‐Risk (OARs). A radiobiological analysis was also performed using the Equivalent Uniform Dose (EUD), mean survival fraction (S) and Tumor Control Probability (TCP) for the PTV, and the Normal Tissue Control Probability (N TCP) and the generalized EUD (gEUD) for the OARs. Significance testing of the observed differences performed using the Wilcoxon paired sample test. Results: Differences between TG43 and MC DVH indices, associated with the increased corresponding local % dose differences observed, were statistically significant. This is mainly attributed to their consistency however, since TG43 agrees closely with MC for the majority of DVH and radiobiological parameters in both patient cohorts. Differences varied considerably among patients only for the ipsilateral lung and ribs in the APBI cohort, with a strong correlation to target location. Conclusion: While the consistency and magnitude of differences in the majority of clinically relevant DVH indices imply that no change is needed in the treatment planning practice, individualized dosimetry improves accuracy and addresses instances of inter‐patient variability observed. Research co‐financed by the ESF and Greek funds through ... |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1118/1.4924942 |
| DOI: |
10.1118/1.4924942/fullpdf |
| الإتاحة: |
https://doi.org/10.1118/1.4924942Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.91DBEB42 |
| قاعدة البيانات: |
BASE |
