دورية أكاديمية
Clinical and inflammatory characteristics of patients with asthma in the Spanish MEGA project cohort
| العنوان: | Clinical and inflammatory characteristics of patients with asthma in the Spanish MEGA project cohort |
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| المؤلفون: | Rial, Manuel J., Álvarez‐Puebla, Maria J., Arismendi, Ebymar, Caballero, María L., Cañas, José A., Cruz Carmona, Mª Jesús, Muñoz Gall, Fco. Javier, Romero Mesones, Christian Eduardo |
| المساهمون: | Institut Català de la Salut, Rial MJ Servicio de Alergología, Departamento de Inmunología, Instituto de Investigación Sanitaria (IIS) Fundación Jiménez Díaz, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain. Álvarez-Puebla MJ Servicio de Alergología, Complejo Hospitalario de Navarra, Pamplona, Spain. Arismendi E CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain. Servicio de Neumología y Alergia, Hospital Clínic, IDIBAPS, Universitat de Barcelona, Barcelona, Spain. Caballero ML Servicio de Alergia, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain. Cañas JA Servicio de Alergología, Departamento de Inmunología, Instituto de Investigación Sanitaria (IIS) Fundación Jiménez Díaz, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain. CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain. Cruz MJ, Muñoz X CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain. Departament de Biologia Cel·lular, Fisiologia i Immunologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Pneumologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Wiley |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Asma - Diagnòstic - Espanya, Asma - Estudi de casos, DISEASES::Respiratory Tract Diseases::Bronchial Diseases::Asthma, Other subheadings::Other subheadings::/diagnosis, GEOGRAPHICALS::Geographic Locations::Europe::Spain, PUBLICATION CHARACTERISTICS::Study Characteristics::Multicenter Study, ENFERMEDADES::enfermedades respiratorias::enfermedades bronquiales::asma, Otros calificadores::Otros calificadores::/diagnóstico, DENOMINACIONES GEOGRÁFICAS::localizaciones geográficas::Europa (continente)::España, CARACTERÍSTICAS DE PUBLICACIONES::características del estudio::estudio multicéntrico |
| الوصف: | Asthma; Inflammation; Phenotype ; Asma; Inflamación; Fenotipos ; Asma; Inflamació; Fenotips ; Introduction The MEGA (MEchanism underlying the Genesis and evolution of Asthma) project is a multicenter cohort study carried out in eight Spanish hospitals, gathering clinical, physiological, and molecular data from patients with asthma and multimorbidities in order to gain insight into the different physiopathological mechanisms involved in this disorder. Material and Methods We report the baseline clinical and physiological characteristics and biomarker measures of adult participants in the project with the aim of better understanding the natural history and underlying mechanisms of asthma as well as the associated multimorbidities across different levels of severity. We carried out a detailed clinical examination, pulmonary function testing, measurement of fractional exhaled nitric oxide (FeNO), blood counts, induced sputum, skin prick tests, chest computed tomography scan, asthma questionnaires, and multimorbidity assessment in 512 asthmatic patients. Results When compared to patients with milder disease, severe asthmatic patients showed greater presence of symptoms, more exacerbations, lower asthma control, increased airflow obstruction, and higher frequency of chronic rhinosinusitis with nasal polyps, severe rhinitis, anxiety and depression, gastroesophageal reflux, and bronchiectasis. Conclusion The MEGA project succeeded in recruiting a high number of asthma patients, especially those with severe disease, who showed lower control and higher frequency of multimorbidities. ; This study was supported by Sanofi [02/055], Fondo de Investigación Sanitaria–FIS [PI15/00803], [PI15/01900], the Merck Health Foundation, CIBER de Enfermedades Respiratorias (CIBERES), a Carlos III Institute of Health initiative, and FEDER funds. The authors recognize Oliver Shaw, English editor of IIS-FJD, for his revision and editing of the manuscript, and Ignacio Mahillo-Fernández for statistical revision. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-0-00-643742-0 0-00-643742-7 |
| تدمد: | 2045-7022 |
| العلاقة: | Clinical and Translational Allergy;11; https://doi.org/10.1002/clt2.12001Test; info:eu-repo/grantAgreement/ES/PE2013-2016/PI15%2F00803; info:eu-repo/grantAgreement/ES/PE2013-2016/PI15%2F01900; Rial MJ, Álvarez-Puebla MJ, Arismendi E, Caballero ML, Cañas JA, Cruz MJ, et al. Clinical and inflammatory characteristics of patients with asthma in the Spanish MEGA project cohort. Clin Transl Allergy. 2021 Mar;11:e12001.; https://hdl.handle.net/11351/6651Test; 000643742700005 |
| DOI: | 10.1002/clt2.12001 |
| الإتاحة: | https://doi.org/10.1002/clt2.12001Test https://hdl.handle.net/11351/6651Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.449A5CD1 |
| قاعدة البيانات: | BASE |
Full Text Finder | ردمك: | 9780006437420 0006437427 |
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| تدمد: | 20457022 |
| DOI: | 10.1002/clt2.12001 |