المؤلفون: Cho, Sung Hwan, Suh, Jun Min, Jeong, Beomgyun, Lee, Tae Hyung, Choi, Kyoung Soon, Eom, Tae Hoon, Choi, Seung Won, Nam, Gi Baek, Kim, Yeong Jae, Jang, Ho Won

المساهمون: Rural Development Administration, Ministry of Science and ICT, South Korea

المصدر: Small ; ISSN 1613-6810 1613-6829

الوصف: The development of hydrogen (H 2 ) gas sensors is essential for the safe and efficient adoption of H 2 gas as a clean, renewable energy source in the challenges against climate change, given its flammability and associated safety risks. Among various H 2 sensors, gasochromic sensors have attracted great interest due to their highly intuitive and low power operation, but slow kinetics, especially slow recovery rate limited its further practical application. This study introduces Pd‐decorated amorphous WO 3 nanorods (Pd‐WO 3 NRs) as an innovative gasochromic H 2 sensor, demonstrating rapid and highly reversible color changes for H 2 detection. In specific, the amorphous nanostructure exhibits notable porosity, enabling rapid detection and recovery by facilitating effective H 2 gas interaction and efficient diffusion of hydrogen ions (H + ) dissociated from the Pd nanoparticles (Pd NPs). The optimized Pd‐WO 3 NRs sensor achieves an impressive response time of 14 s and a recovery time of 1 s to 5% H 2 . The impressively fast recovery time of 1 s is observed under a wide range of H 2 concentrations (0.2–5%), making this study a fundamental solution to the challenged slow recovery of gasochromic H 2 sensors.

الإتاحة: https://doi.org/10.1002/smll.202309744Test

المؤلفون: Min‐Jee Lee, Yeong‐Geun Lee, You Jin Lim, Kyeong‐Hwa Seo, Seok‐Hyun Eom, Se Chan Kang, Nam‐In Baek, Youn‐Hyung Lee

المصدر: Chemistry & Biodiversity. 20

مصطلحات موضوعية: Molecular Medicine, Bioengineering, General Chemistry, General Medicine, Molecular Biology, Biochemistry

الوصف: Investigation of phytochemicals in Prunus davidiana fruits led to the isolation of 13 phenolic compounds: five flavonoids ( 1 - 5 ), four phenylpropanoids ( 6-9 ), two lignans ( 10 and 11 ), one benzoic glycoside ( 12 ), and one cyanobenzyl glycoside ( 13 ). All phenolic compounds were reported for the first time from P. davidiana fruits in this study. The chemical structures of 1 - 13 were decided using various spectroscopic analyses such as MS, IR, and NMR. As well, the occurrence of the isolated ones in Prunus species was discussed. All compounds were evaluated for radical scavenging activity using ABTS and DPPH radicals. Compounds 2 , 5 , 6 , 8 , 9 , and 11 had much higher scavenging activity than ascorbic acid, a well-known antioxidant.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f130c8a96d3add2e9c78af12ee723e3aTest
https://doi.org/10.1002/cbdv.202200823Test

المؤلفون: Jung-Hwan Ko, Nam-In Baek, Dae Young Lee, Sae‐Chan Kang, Hyoung-Geun Kim, Hyun-Ji Oh, Yeong-Geun Lee, Jung-Hwa Kwon, Hae Seong Song

المصدر: Bulletin of the Korean Chemical Society. 39:687-690

مصطلحات موضوعية: 0106 biological sciences, chemistry.chemical_classification, Traditional medicine, biology, 010405 organic chemistry, Chemistry, Glycoside, General Chemistry, biology.organism_classification, 01 natural sciences, 0104 chemical sciences, Benzonitrile, chemistry.chemical_compound, 010608 biotechnology, Brugmansia, Cytotoxic T cell, Cytotoxicity

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::7eda0ecf50d02e88f8acaa57a70f43e1Test
https://doi.org/10.1002/bkcs.11451Test

المؤلفون: Ju-Ha Kim, Sung-Hoon Kim, Jung Hyo Kim, Young-Hwan Kim, Ok Heui You, Hyemin Lee, Jae-Ho Khil, Deok Yong Sim, Eun Ah Shin, Nam-In Baek

المصدر: Phytotherapy Research. 31:1614-1620

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, education.field_of_study, biology, Poly ADP ribose polymerase, Population, Caspase 3, Molecular biology, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Cyclin D1, chemistry, Apoptosis, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Ectopic expression, Astragalin, education, neoplasms, Caspase

الوصف: Though Astragalin (kaempferol-3-glucoside) contained in Paeonia lactiflora and other plants was known to have anti-oxidant, antiinflammatory, and anti-tumor activity, the anti-tumor mechanism of Astragalin has never been reported in melanomas until now. Thus, in the present study, the underlying apoptotic mechanism of Astragalin isolated from Aceriphyllum rossii was elucidated in A375P and SK-MEL-2 melanoma cells. Astragalin exerted cytotoxicity in A375P and SK-MEL-2 cells in a concentration-dependent manner. Also, Astragalin significantly increased the number of TdT-mediated dUTP nick end labeling positive cells and sub-G1 population as a feature of apoptosis in A375P and SK-MEL-2 cells compared with untreated control. Consistently, western blotting revealed that Astragalin activated caspase 9/3 and Bax, cleaved poly (ADP-ribose) polymerase, and attenuated the expression of cyclin D1, Mcl-1, and Sry-related HMg-Box gene 10 (SOX10) in A375P and SK-MEL-2 cells. Of note, ectopic expression of SOX10 reduced the apoptotic ability of Astragalin to inhibit proliferation, cleave poly (ADP-ribose) polymerase, and caspase 3 in A375P and SK-MEL-2 melanoma cells. Overall, our findings provide evidence that Astragalin induces apoptosis in A375P and SK-MEL-2 melanoma cells via activation of caspase9/3 and inhibition of SOX10 signaling. Copyright © 2017 John Wiley & Sons, Ltd.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b18ef4d849457be9aa74a62e6c78d7efTest
https://doi.org/10.1002/ptr.5895Test

المؤلفون: Meade, Jessica, Nam, Ki‐Baek, Beckerman, Andrew P., Hatchwell, Ben J.

المصدر: Journal of Animal Ecology ; volume 79, issue 3, page 529-537 ; ISSN 0021-8790 1365-2656

الوصف: Summary 1. Helpers that invest energy in provisioning the offspring of related individuals stand to gain indirect fitness benefits from doing so. First, if the helper’s effort is additional to that of the parents (additive) the productivity of the current breeding attempt can be increased. Secondly, if the parents reduce their workload (compensation) this can result in future indirect fitness gains to the helper via increased breeder survival; termed ‘load‐lightening’. 2. Long‐tailed tits ( Aegithalos caudatus ) have a cooperative breeding system in which helpers assist kin and parents exhibit both additive and compensatory reactions in the presence of helpers. Offspring from helped nests are heavier and more likely to recruit into the breeding population, thus helpers gain indirect fitness benefits from increasing the productivity of the current breeding attempt. Despite breeders’ reduction of feeding effort in the presence of helpers, previous investigations found no subsequent increase in breeder survival. 3. The aim of this study was to test the hypothesis that load‐lightening resulted in indirect fitness benefits for helpers. We used data from a 14‐year study to investigate the provisioning rate, survival and future fecundity of male and female long‐tailed tits that did and did not receive help at the nest. 4. We found an asymmetrical response to the presence of helpers at large brood sizes. Males reduced their feeding rate more than females, and this differential response was reflected in a significant increase in male survival when provisioning large broods assisted by helpers. We found no evidence of any increase in future fecundity for helped breeders. 5. The finding that males reduce their provisioning rate in the presence of helpers (at large brood sizes) to a greater degree than females, and that this is reflected in an increase in survival rate for males only, implies that the survival increase is caused by the reduction in work‐rate rather than a non‐specific benefit of a larger group size. 6. The ...

الإتاحة: https://doi.org/10.1111/j.1365-2656.2009.01656.xTest

المؤلفون: Eun Jung Sohn, Joe Young Kim, Sung-Hoon Kim, Ji Hyun Lee, Nam-In Baek, Sang Wook Yoon, Chang Geun Kim, Sangil Lee

المصدر: Phytotherapy Research. 31:441-448

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Cell, Transfection, Matrix metalloproteinase, Biology, MMP9, Cell biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Apoptosis, 030220 oncology & carcinogenesis, Cancer research, medicine, Cytotoxic T cell, Cytotoxicity, B cell

الوصف: Though Dehydrocorydaline, an alkaloid isolated from Corydalis turtschaninovii tuber, was known to have anti-coronary artery disease, anti-inflammatory, apoptotic, anti-allergic, anti-acetylcholinesterase, and antitumor effects, the underlying anti-metastatic mechanism of Dehydrocorydalin was never elucidated in lung cancer cells so far. Thus, in the present study, the anti-metastatic effect of Dehydrocorydaline was examined in non-small cell lung carcinoma (NSCLC) cells, mainly targeting matrix metalloproteinases (MMPs) and B cell lymphoma-2 (Bcl-2) signaling. Here, Dehydrocorydaline exerted weak cytotoxicity and attenuated the protein expression of Bcl-2 and activated Bax in a concentration-dependent manner in NSCLC cells, such as A549, H460, H1299, and H596 cells. Also, Dehydrocorydaline suppressed the migration of H1299 cells by wound healing assay and transwell migration assay. Consistently, Dehydrocorydaline attenuated mRNA and protein levels of MMP7 and MMP9 as metastasis biomarkers in H1299 cells by quantitative reverse transcription polymerase chain reaction. Of note, Bcl-2 overexpression reduced the cytotoxic and anti-metastatic effects of Dehydrocorydaline on pCDNA-Bcl-2 transfected H1299 cells. Overall, our findings provide scientific evidence that Dehydrocorydaline exerts anti-metastatic potential via suppression of MMPs and Bcl-2 signaling in NSCLC cells. Copyright © 2017 John Wiley & Sons, Ltd.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::432cfd2dd2c656f46bf51fecba37db7cTest
https://doi.org/10.1002/ptr.5766Test

المؤلفون: Eun Ah Shin, Sung-Hoon Kim, Chang Geun Kim, Bonglee Kim, Nam-In Baek, Dae Young Lee, Hee Jeong Kim

المصدر: Phytotherapy Research. 30:1841-1847

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Transcription Factor CHOP, biology, CHOP, respiratory tract diseases, Cell biology, Biphenyl compound, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Cyclin D1, chemistry, Downregulation and upregulation, Apoptosis, 030220 oncology & carcinogenesis, biology.protein, Obovatol, Caspase

الوصف: Although obovatol, a phenolic compound from the bark of Magnolia obovata, was known to have antioxidant, neuroprotective, antiinflammatory, antithrombotic and antitumour effects, its underlying antitumour mechanism is poorly understood so far. Thus, in the present study, the antitumour molecular mechanism of obovatol was investigated in non-small cell lung cancer cells (NSCLCs). Obovatol exerted cytotoxicity in A549 and H460 NSCLCs, but not in BEAS-2B cells. Also, obovatol increased sub-G1 accumulation and early and late apoptotic portion in A549 and H460 NSCLCs. Consistently, obovatol cleaved PARP, activated caspase 9/3 and Bax and attenuated the expression of cyclin D1 in A549 and H460 NSCLCs. Interestingly, obovatol upregulated the expression of endoplasmic reticulum stress proteins such as C/EBP homologous protein (CHOP), IRE1α, ATF4 and p-elF2 in A549 and H460 NSCLCs. Conversely, depletion of CHOP blocked the apoptotic activity of obovatol to increase sub-G1 accumulation in A549 and H460 NSCLCs. Overall, our findings support scientific evidences that obovatol induces apoptosis via CHOP activation in A549 and H460 NSCLCs. Copyright © 2016 John Wiley & Sons, Ltd.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::710f81d8f51039657b1e17336015f8c9Test
https://doi.org/10.1002/ptr.5690Test

المؤلفون: Dong-Sung Lee, Youn-Chul Kim, Dae Young Lee, Youn-Hyung Lee, Kyeong-Hwa Seo, Nam-In Baek, Jae-Woo Jung

المصدر: Helvetica Chimica Acta. 99:411-415

مصطلحات موضوعية: biology, Traditional medicine, 010405 organic chemistry, Chemistry, Stereochemistry, Organic Chemistry, biology.organism_classification, 030226 pharmacology & pharmacy, 01 natural sciences, Biochemistry, Neuroprotection, Catalysis, 0104 chemical sciences, Inorganic Chemistry, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Physical and Theoretical Chemistry, No production, Magnolia obovata

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::cbf99e5cb458ea13c00cd657496b98eaTest
https://doi.org/10.1002/hlca.201500101Test

المؤلفون: Hyunjoo Lee, Hye-Eun Joo, Sung-Hoon Kim, Hangil Kim, Eun Ah Shin, Bonglee Kim, Nam-In Baek, Kyeong-Hwa Seo

المصدر: Phytotherapy Research. 30:596-603

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, education.field_of_study, biology, Kinase, Endoplasmic reticulum, c-jun, Population, Caspase 3, Molecular biology, respiratory tract diseases, 03 medical and health sciences, 030104 developmental biology, Bcl-2-associated X protein, Apoptosis, biology.protein, Unfolded protein response, education

الوصف: Though arjunic acid, a triterpene isolated from Terminalia arjuna, was known to have antioxidant, antiinflammatory, and cytotoxic effects, its underlying antitumor mechanism still remains unclear so far. Thus, in the present study, the molecular antitumor mechanism of arjunic acid was examined in A549 and H460 non-small cell lung cancer (NSCLC) cells. Arjunic acid exerted cytotoxicity by 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl tetrazolium bromide (MTT) assay and significantly increased sub-G1 population in A549 and H460 cells by cell cycle analysis. Consistently, arjunic acid cleaved poly (ADP-ribose) polymerase (PARP), activated Bax, and phosphorylation of c-Jun N-terminal kinases (JNK), and also attenuated the expression of pro-caspase-3 and Bcl-2 in A549 and H460 cells. Furthermore, arjunic acid upregulated the expression of endoplasmic reticulum (ER) stress proteins such as IRE1 α, ATF4, p-eIF2α, and C/EBP homologous protein (CHOP) in A549 and H460 cells. Conversely, CHOP depletion attenuated the increase of sub-G1 population by arjunic acid, and also JNK inhibitor SP600125 blocked the cytotoxicity and upregulation of IRE1 α and CHOP induced by arjunic acid in A549 and H460 cells. Overall, our findings suggest that arjunic acid induces apoptosis in NSCLC cells via JNK mediated ER stress pathway as a potent chemotherapeutic agent for NSCLC.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::25c3747c5de969d6530a54f13f72f498Test
https://doi.org/10.1002/ptr.5563Test

المؤلفون: Bo-Im Kim, Moon Sik Nam, Deok-Beom Jung, Sung-Hoon Kim, Ju-Ha Kim, Bonglee Kim, Nam-In Baek, Jung Hyo Kim, Kyeong-Hwa Seo

المصدر: Phytotherapy Research. 30:90-96

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, endocrine system diseases, biology, Adenosine diphosphate ribose, Poly ADP ribose polymerase, NF-κB, Molecular biology, female genital diseases and pregnancy complications, 03 medical and health sciences, chemistry.chemical_compound, IκBα, 030104 developmental biology, 0302 clinical medicine, Cyclin D1, chemistry, Apoptosis, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Cytotoxic T cell, Caspase

الوصف: In the present study, the underlying apoptotic mechanism of sanggenol L was elucidated in ovarian cancer cells. Sanggenol L showed cytotoxic and antiproliferative effect in A2780, SKOV-3, and OVCAR-3 ovarian cancer cells in a concentration-dependent fashion. Consistently, sanggenol L increased sub-G1 phase population and early and late apoptotic portion in ovarian cancer cells. Also, sanggenol L activated caspase9/3, suppressed the phosphorylation of IκBα and p65 NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells), attenuated the expression of Cyclin D1, and cleaved poly(adenosine diphosphate ribose -ribose) polymerase in SKOV-3, A2780, and OVCAR-3 cells. Furthermore, sanggenol L blocked nuclear translocation of NF-κB and also attenuated the expression of NF-κB related genes such as c-Myc, Cyclin D1, and Bcl-X L, Bcl-2, in lipopolysaccharide-treated SKOV-3 cells. Overall, our findings for the first time suggest that sanggenol L induces apoptosis via caspase activation and inhibition of NF-κB/IκBα phosphorylation as a potent chemotherapeutic agent for ovarian cancers.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a2b69ac0dc5ee2d08282ccd2b2a573a9Test
https://doi.org/10.1002/ptr.5505Test