التفاصيل البيبلوغرافية
| العنوان: |
Comparison of Clinical Outcomes Between Low‐ and High‐Risk Groups of Early Breast Cancer Patients Treated with Intraoperative Radiotherapy in Addition to External Beam Radiation: A Multi‐Centre Prospective Study |
| المؤلفون: |
Mosiun, J. A., See, Mee‐Hoong, Teoh, Li‐Ying, Danaee, Mahmoud, Lai, Lee‐Lee, Ng, Char‐Hong, Yip, Cheng‐Har, Teh, Mei‐Sze, Taib, Nur Aishah Md, Bustam, Anita, Malik, Rozita Abdul, Saad, Marniza, Jamaris, Suniza, Ung, Ngie‐Min |
| المصدر: |
World Journal of Surgery ; volume 47, issue 1, page 201-208 ; ISSN 0364-2313 1432-2323 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2022 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Background There is a paucity of data on the use of intraoperative radiotherapy (IORT) with low‐energy X‐rays in Malaysian women with early breast cancer. The aim of this study is to evaluate the clinical, cosmetic, and patient‐reported outcomes in low‐ and high‐risk early breast cancer patients treated with breast conserving surgery (BCS) and IORT. Methodology Patients suitable for BCS who were treated with IORT between January 2016 and June 2019 from three centres were analysed. They were divided into low‐risk and high‐risk groups based on the risk of recurrence according to the TARGeted Intraoperative radioTherapy (TARGIT) A and B study criteria. Outcomes of interest included local recurrence, wound complications, and radiation toxicity, with a subset analysed for cosmetic and patient‐reported outcomes. Results Within a median follow‐up of 31 months, there were 104 and 211 patients in the low‐ and high‐risk groups, respectively. No significant difference was observed in local recurrence rates (low‐risk, 1.0% vs. high‐risk, 1.4%; p = 1.000). Both cohorts exhibited low frequencies of severe wound complications ranging between 1.4 and 1.9%. No major radiation toxicities were reported in either group. In the subgroup analysis, low‐risk patients had significantly better mean scores in the subscales of inframammary fold and scar. Based on the BREAST‐Q patient‐reported outcomes questionnaire, seven out of nine parameters were scored similarly between both groups with no significant difference. Conclusion This study showed that the use of IORT in both low‐ and high‐risk early breast cancers is efficacious and safe with low recurrence rates and an acceptable toxicity profile. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1007/s00268-022-06753-0 |
| DOI: |
10.1007/s00268-022-06753-0.pdf |
| DOI: |
10.1007/s00268-022-06753-0/fulltext.html |
| الإتاحة: |
https://doi.org/10.1007/s00268-022-06753-0Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest ; https://www.springernature.com/gp/researchers/text-and-data-miningTest ; https://www.springernature.com/gp/researchers/text-and-data-miningTest |
| رقم الانضمام: |
edsbas.70A28310 |
| قاعدة البيانات: |
BASE |
