التفاصيل البيبلوغرافية
العنوان:
Octahydrogenated retinoic acid-conjugated glycol chitosan nanoparticles as a novel carrier of azadirachtin: Synthesis, characterization, and in vitro evaluation
المؤلفون:
Qing-Peng Zhang , Zhixiang Zhang , Meng-Ling Lu , Hanhong Xu , Lu Wei , Yongqing Tian
المصدر:
Journal of Polymer Science Part A: Polymer Chemistry . 51:3932-3940
بيانات النشر:
Wiley, 2013.
سنة النشر:
2013
مصطلحات موضوعية:
Polymers and Plastics , Biocompatibility , Chemistry , Organic Chemistry , Nanoparticle , Environmental pollution , Conjugated system , Controlled release , Amphiphile , Materials Chemistry , Organic chemistry , Nanocarriers , Cytotoxicity , Nuclear chemistry
الوصف:
Environment-friendly and controlled release formulation is highly promising for reducing environmental pollution and achieving the most effective utilization of pesticides. As a novel “green” nanocarrier of pesticides, amphiphilic self-assembled nanoparticles were prepared by chemical conjugation of octahydrogenated retinoic acid (OR) to the backbone of glycol chitosan (GC). In aqueous media, the synthesized OR-GC conjugates formed nanosized particles with a diameter of 257 nm. Hydrophobic azadirachtin (AZA) was efficiently loaded into the OR-GC nanoparticles at a feed weight ratio of up to 1:4 using a simple dialysis method, the maximum drug-loading efficiency of which was 74%. AZA-OR-GC (25 wt %) nanoparticles also showed sustained release of the incorporated AZA (65% of the loaded dose was released in 7 days at 27 °C in phosphate-buffered saline; pH 7.2). Cytotoxicity tests and cell cycle arrest assays confirmed that OR-GC exhibits good biocompatibility; AZA-OR-GC (25 wt %) nanoparticles also showed favorable inhibition of cell proliferation in Sl-1 cells compared with free AZA in organic solvents. Overall, controlled release AZA-OR-GC may be a promising environment-friendly formulation for integrated pest management. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 3932–3940
تدمد:
0887-624X
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_________::18b72d5f00de8c6036e8ab9010dee278Test https://doi.org/10.1002/pola.26801Test
حقوق:
CLOSED
رقم الانضمام:
edsair.doi...........18b72d5f00de8c6036e8ab9010dee278
قاعدة البيانات:
OpenAIRE
