دورية أكاديمية
Links between psychopathological symptoms and cortical thickness in men with severe alcohol use disorder: A Magnetic Resonance Imaging study
| العنوان: | Links between psychopathological symptoms and cortical thickness in men with severe alcohol use disorder: A Magnetic Resonance Imaging study |
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| المؤلفون: | Géraldine Petit, Sophie Leclercq, Caroline Quoilin, Marie Poncin, Peter Starkel, Pierre Maurage, Benjamin Rolland, Laurence Dricot, Philippe De Timary |
| المصدر: | Neuropsychopharmacology Reports, Vol 43, Iss 4, Pp 513-520 (2023) |
| بيانات النشر: | Wiley, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Therapeutics. Pharmacology LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: | abstinence, alcohol use disorders, anxiety, cortical thickness, depression, Therapeutics. Pharmacology, RM1-950, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | Abstract Background Anxiety and depression are psychopathological states frequently co‐occurring with severe alcohol use disorder (SAUD). These symptoms generally disappear with abstinence but may persist in some patients, increasing the relapse risk. Methods The cerebral cortex thickness of 94 male patients with SAUD was correlated with symptoms of depression and anxiety, both measured at the end (2–3 weeks) of the detoxification treatment. Cortical measures were obtained using surface‐based morphometry implemented with Freesurfer. Results Depressive symptoms were associated with reduced cortical thickness in the superior temporal gyrus of the right hemisphere. Anxiety level was correlated with lower cortical thickness in the rostral middle frontal region, inferior temporal region, and supramarginal, postcentral, superior temporal, and transverse temporal regions of the left hemisphere, as well as with a large cluster in the middle temporal region of the right hemisphere. Conclusions At the end of the detoxification stage, the intensity of depressive and anxiety symptoms is inversely associated with the cortical thickness of regions involved in emotions‐related processes, and the persistence of the symptoms could be explained by these brain deficits. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2574-173X |
| العلاقة: | https://doaj.org/toc/2574-173XTest |
| DOI: | 10.1002/npr2.12331 |
| الوصول الحر: | https://doaj.org/article/7c24cb06a71641ab99330f7da6b5add4Test |
| رقم الانضمام: | edsdoj.7c24cb06a71641ab99330f7da6b5add4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2574173X |
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| DOI: | 10.1002/npr2.12331 |