التفاصيل البيبلوغرافية
| العنوان: |
Microembolic signal monitoring in patients with HeartMate 3 and HeartWare left ventricular assist devices: Association with antithrombotic treatment and cerebrovascular events |
| المؤلفون: |
Ravenberg, Kim Kristin, Gabriel, Maria Magdalena, Leotescu, Andrei, Tran, Anh Thu, Grosse, Gerrit Maximilian, Schuppner, Ramona, Ernst, Johanna, Lichtinghagen, Ralf, Tiede, Andreas, Werwitzke, Sonja, Bara, Christoph Leon, Schmitto, Jan Dieter, Weissenborn, Karin, Hanke, Jasmin Sarah, Worthmann, Hans |
| المساهمون: |
Else Kröner-Fresenius-Stiftung |
| المصدر: |
Artificial Organs ; volume 47, issue 2, page 370-379 ; ISSN 0160-564X 1525-1594 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2022 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Background In patients with left ventricular assist devices (LVADs), ischemic and hemorrhagic stroke are dreaded complications. Predictive markers for these events are lacking. This study aimed to investigate the prevalence and predictive value of microembolic signals (MES) for stroke, detected by Transcranial Doppler sonography (TCD) in patients with HeartMate 3 (HM 3) or HeartWare (HW). Methods A thirty‐minute bilateral TCD monitoring of the middle cerebral artery (MCA) was performed in 62 outpatients with LVAD (HM 3 N = 31, HW N = 31) and 31 healthy controls. Prevalence and quantity of MES were investigated regarding clinical and laboratory parameters. Cerebrovascular events (CVE) were recorded on follow‐up at 90 and 180 days. Results MES were detected in six patients with HM 3, three patients with HW, and three controls. Within the LVAD groups, patients on monotherapy with vitamin‐K‐antagonist (VKA) without antiplatelet therapy were at risk for a higher count of MES (negative binomial regression: VKA: 1; VKA + ASA: Exp(B) = 0.005, 95%CI 0.001–0.044; VKA + clopidogrel: Exp(B) = 0.012, 95%CI 0.002–0.056). There was no association between the presence of MES and CVE or death on follow‐up ( p > 0.05). Conclusion For the first time, the prevalence of MES was prospectively investigated in a notable outpatient cohort of patients with HM 3 and HW. Despite optimized properties of the latest LVAD, MES remain detectable depending on antithrombotic therapy. No association between MES and CVE could be detected. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/aor.14409 |
| الإتاحة: |
https://doi.org/10.1111/aor.14409Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.F83DD1AD |
| قاعدة البيانات: |
BASE |
