Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non‐Alzheimer's disease pathophysiology
| العنوان: | Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non‐Alzheimer's disease pathophysiology |
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| المؤلفون: | Aurore Delvenne, Johan Gobom, Betty Tijms, Isabelle Bos, Lianne M. Reus, Valerija Dobricic, Mara ten Kate, Frans Verhey, Inez Ramakers, Philip Scheltens, Charlotte E. Teunissen, Rik Vandenberghe, Jolien Schaeverbeke, Silvy Gabel, Julius Popp, Gwendoline Peyratout, Pablo Martinez‐Lage, Mikel Tainta, Magda Tsolaki, Yvonne Freund‐Levi, Simon Lovestone, Johannes Streffer, Frederik Barkhof, Lars Bertram, Kaj Blennow, Henrik Zetterberg, Pieter Jelle Visser, Stephanie J. B. Vos |
| المساهمون: | Neurology, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Neurodegeneration, Radiology and nuclear medicine, Clinical chemistry, Amsterdam Neuroscience - Neuroinfection & -inflammation, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Psychology 6, Psychiatrie & Neuropsychologie, MUMC+: MA Med Staf Spec Psychiatrie (9), Psychology 2 |
| المصدر: | Alzheimer's & dementia Delvenne, A, Gobom, J, Tijms, B, Bos, I, Reus, L M, Dobricic, V, Kate, M T, Verhey, F, Ramakers, I, Scheltens, P, Teunissen, C E, Vandenberghe, R, Schaeverbeke, J, Gabel, S, Popp, J, Peyratout, G, Martinez-Lage, P, Tainta, M, Tsolaki, M, Freund-Levi, Y, Lovestone, S, Streffer, J, Barkhof, F, Bertram, L, Blennow, K, Zetterberg, H, Visser, P J & Vos, S J B 2022, ' Cerebrospinal fluid proteomic profiling of individuals with mild cognitive impairment and suspected non-Alzheimer's disease pathophysiology ', Alzheimer's and Dementia . https://doi.org/10.1002/alz.12713Test Alzheimer's and Dementia. Elsevier Alzheimer's & Dementia, 19(3), 807-820. Elsevier Science |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Epidemiology, Clinical Neurology, PROTEIN, behavioral disciplines and activities, cerebrospinal fluid, Cellular and Molecular Neuroscience, mild cognitive impairment, proteomics, ADULT, Developmental Neuroscience, mental disorders, tau, pathophysiology, Science & Technology, suspected non-Alzheimer's disease pathophysiology, Health Policy, biomarkers, Alzheimer's disease, nervous system diseases, Psychiatry and Mental health, Neurosciences & Neurology, Human medicine, Neurology (clinical), Geriatrics and Gerontology, Life Sciences & Biomedicine, human activities |
| الوصف: | BACKGROUND: Suspected non-Alzheimer's disease pathophysiology (SNAP) is a biomarker concept that encompasses individuals with neuronal injury but without amyloidosis. We aim to investigate the pathophysiology of SNAP, defined as abnormal tau without amyloidosis, in individuals with mild cognitive impairment (MCI) by cerebrospinal fluid (CSF) proteomics. METHODS: Individuals were classified based on CSF amyloid beta (Aβ)1-42 (A) and phosphorylated tau (T), as cognitively normal A-T- (CN), MCI A-T+ (MCI-SNAP), and MCI A+T+ (MCI-AD). Proteomics analyses, Gene Ontology (GO), brain cell expression, and gene expression analyses in brain regions of interest were performed. RESULTS: A total of 96 proteins were decreased in MCI-SNAP compared to CN and MCI-AD. These proteins were enriched for extracellular matrix (ECM), hemostasis, immune system, protein processing/degradation, lipids, and synapse. Fifty-one percent were enriched for expression in the choroid plexus. CONCLUSION: The pathophysiology of MCI-SNAP (A-T+) is distinct from that of MCI-AD. Our findings highlight the need for a different treatment in MCI-SNAP compared to MCI-AD. ispartof: ALZHEIMERS & DEMENTIA vol:19 issue:3 pages:807-820 ispartof: location:United States status: published |
| وصف الملف: | Print-Electronic |
| تدمد: | 1552-5279 1552-5260 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0cefafaf25dc245841c892465ac470Test https://doi.org/10.1002/alz.12713Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8f0cefafaf25dc245841c892465ac470 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15525279 15525260 |
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