التفاصيل البيبلوغرافية
| العنوان: |
The assessment of aspirin resistance by using light transmission and multiple electrode aggregometry |
| المؤلفون: |
ULEHLOVA, J., SLAVIK, L., KRCOVA, V., HUTYRA, M., GALUSZKA, J., INDRAK, K. |
| المصدر: |
International Journal of Laboratory Hematology ; volume 33, issue 3, page 305-309 ; ISSN 1751-5521 1751-553X |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2011 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Summary Introduction: The issues related to aspirin [acetylsalicylic acid (ASA)] resistance are still under debate. Depending on the method of assessment and studied patients, the prevalence of ASA resistance is rather heterogeneous, ranging from 5% to 45%. The method most commonly used for assessing platelet function is their aggregation. ASA irreversibly inhibits cyclooxygenase‐1 (COX‐1) by acetylation. Methods: This study aimed to compare light transmission aggregometry (LTA) and multiple electrode aggregometry (MEA) for the measurement of ASA resistance, using arachidonic acid as an inducer of the reaction. Results: The study comprised 101 patients with stable ischemic heart disease taking a daily dose of 100 mg of ASA. The rates of ASA resistance were 22.22% and 21.21% as detected by LTA and MEA, respectively. The two methods were statistically compared using Spearman’s nonparametric correlation analysis, with a positive significant correlation ( P = 0.01) and medium positive dependence between the methods ( r = 0.0539). Conclusion: If ASA resistance is detected by laboratory tests, replacement of ASA or its combination with other antiplatelet drugs as well as increased dosage may be considered. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1111/j.1751-553x.2010.01286.x |
| DOI: |
10.1111/j.1751-553X.2010.01286.x |
| الإتاحة: |
https://doi.org/10.1111/j.1751-553x.2010.01286.xTest |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.11D3BA84 |
| قاعدة البيانات: |
BASE |
