Outcome and potentially modifiable risk factors for candidemia in critically ill burns patients: A matched cohort study
| العنوان: | Outcome and potentially modifiable risk factors for candidemia in critically ill burns patients: A matched cohort study |
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| المؤلفون: | Blandine Denis, Marc Chaouat, Alexandre Alanio, Christian de Tymowski, Alexandru Cupaciu, David Boccara, François Dépret, Stéphane Bretagne, Haikel Oueslati, Maurice Mimoun, Axelle Ferry, Sabri Soussi, Matthieu Lafaurie, Maud Gits-Muselli, Emmanuel Dudoignon, Maxime Coutrot, Alexandre Fratani, James Anstey, Kevin Serror, Marion Jully, Matthieu Legrand, Maïté Chaussard, Mourad Benyamina, Alexandre Mebazaa |
| المصدر: | Mycoses. 62:237-246 |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Antifungal, medicine.medical_specialty, medicine.drug_class, Critical Illness, 030106 microbiology, Dermatology, Sepsis, 030207 dermatology & venereal diseases, 03 medical and health sciences, fluids and secretions, 0302 clinical medicine, Matched cohort, Risk Factors, hemic and lymphatic diseases, Antibiotic therapy, Internal medicine, medicine, Humans, Aged, Retrospective Studies, Icu mortality, Critically ill, Septic shock, business.industry, Candidemia, General Medicine, Middle Aged, equipment and supplies, bacterial infections and mycoses, medicine.disease, Survival Analysis, Drug Utilization, Anti-Bacterial Agents, Treatment Outcome, Infectious Diseases, Candida spp, Female, Burns, business |
| الوصف: | BACKGROUND Patients with extensive burns are at risk of developing candidemia. OBJECTIVES To identify potentially modifiable risk factors and outcomes of candidemia in critically ill burns patients. PATIENTS AND METHODS Retrospective matched cohort study including adult burns patients. Patients who developed candidemia were matched with burns patients with Candida spp colonisation and sepsis or septic shock without candidemia in a ratio of 1:3 (same severity scores and colonisation index). Univariate and multiple regression analyses were performed. RESULTS Of 130 severely burned patients with Candida spp colonisation and at least one episode of sepsis or septic shock, 14 were diagnosed with candidemia. In the candidemia group, patients had a median (IQR) total burns surface area (TBSA) of 57 (38-68)%, SAPSII of 43 (36-58) and ABSI of 11 (8-13). Multiple regression analysis showed that only duration of prior antibiotic therapy was independently associated with candidemia. ICU mortality was higher in the candidemia group (71% vs 35% [P = 0.02]). The log-rank test for 28-day mortality comparing patients with candidemia treated with an empirical strategy vs a curative strategy did not reach significance (P = 0.056). CONCLUSIONS Burns patients having received recent antibiotherapy have a higher risk of candidemia. Antifungal strategies did not influence outcome in this series. |
| تدمد: | 1439-0507 0933-7407 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fdf52caa51a052d97426ca0ce4700aeTest https://doi.org/10.1111/myc.12872Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....5fdf52caa51a052d97426ca0ce4700ae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14390507 09337407 |
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