المؤلفون: Toshiko Kobori, Yukiko Onishi, Masahiko Iwamoto, Tetsuya Kubota, Takako Kikuchi, Tazu Tahara, Toshiko Takao, Hiroaki Fujiwara, Yoko Yoshida, Masato Kasuga

المصدر: Journal of Diabetes Investigation, Vol 13, Iss 3, Pp 501-504 (2022)

مصطلحات موضوعية: Gastric residue, Gastroparesis, Insulin treatment, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Abstract The purpose of this study was to investigate the association of glycemic control and diabetes treatment to gastric residue observed during an esophagogastroduodenoscopy. Among 6,592 individuals who had esophagogastroduodenoscopy at our clinic between 2003 and 2019, we retrospectively and longitudinally identified those who had gastric residue during an esophagogastroduodenoscopy. Other data collected were age, sex, diagnosis of diabetes, glycated hemoglobin and diabetes medication. Cox proportional hazards models were used to assess the association of these data with the occurrence of gastric residue. To the best of our knowledge, this is the first retrospective cohort study finding that undergoing insulin treatment is a risk factor for gastric residue independent of age, sex and diabetes or glycated hemoglobin.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2040-1116Test; https://doaj.org/toc/2040-1124Test

الوصول الحر: https://doaj.org/article/5e1f10b0db62487bbe4d38e972778db4Test

المؤلفون: Andrews, P.L.R., Golding, J.F., Sanger, G.J.

مصطلحات موضوعية: anti-cancer chemotherapy, gastroparesis, motion sickness, nausea, neurokinin1, substance P, vomiting

الوصف: A broad-spectrum anti-vomiting effect of neurokinin1 receptor antagonists (NK1RA), shown in pre-clinical animal studies, has been supported by a more limited range of clinical studies in different indications. However, this review suggests that compared with vomiting, the self-reported sensation of nausea is less affected or possibly unaffected (depending on the stimulus) by NK1 receptor antagonism, a common finding for anti-emetics. The stimulus-independent effects of NK1RAs against vomiting are explicable by actions within the central pattern generator (ventral brainstem) and the nucleus tractus solitarius (NTS; dorsal brainstem), with additional effects on vagal afferent activity for certain stimuli (e.g., highly emetogenic chemotherapy). The central pattern generator and NTS neurones are multifunctional so the notable lack of obvious effects of NK1RAs on other reflexes mediated by the same neurones suggests that their anti-vomiting action is dependent on the activation state of the pathway leading to vomiting. Nausea requires activation of cerebral pathways by projection of information from the NTS. Although NK1 receptors are present in cerebral nuclei implicated in nausea, and imaging studies show very high receptor occupancy at clinically used doses, the variable or limited ability of NK1RAs to inhibit nausea emphasizes: (i) our inadequate understanding of the mechanisms of nausea; and (ii) that classification of a drug as an anti-emetic may give a false impression of efficacy against nausea vs. vomiting. We discuss the potential mechanisms for the differential efficacy of NK1RA and the implications for future development of drugs that can effectively treat nausea, an area of unmet clinical need.

وصف الملف: application/pdf

العلاقة: https://westminsterresearch.westminster.ac.uk/download/d4a13482bd19f74458b38b2b354780ff8d19f962ae1cb803f3904f6f83c57329/2689072/Brit%20J%20Clinical%20Pharma%20-%202023%20-%20Andrews.pdfTest; https://doi.org/10.1111/bcp.15852Test; Andrews, P.L.R., Golding, J.F. and Sanger, G.J. 2023. An assessment of the effects of neurokinin1 receptor antagonism against nausea and vomiting: Relative efficacy, sites of action and lessons for future drug development. British Journal of Clinical Pharmacology. 89 (12), pp. 3468-3490. https://doi.org/10.1111/bcp.15852Test

الإتاحة: https://doi.org/10.1111/bcp.15852Test
https://westminsterresearch.westminster.ac.uk/item/w4qq6/an-assessment-of-the-effects-of-neurokinin1-receptor-antagonism-against-nausea-and-vomiting-relative-efficacy-sites-of-action-and-lessons-for-future-drug-developmentTest
https://westminsterresearch.westminster.ac.uk/download/d4a13482bd19f74458b38b2b354780ff8d19f962ae1cb803f3904f6f83c57329/2689072/Brit%20J%20Clinical%20Pharma%20-%202023%20-%20Andrews.pdfTest

المؤلفون: Soliman, Heithem, Schalla, Martha, Coffin, Benoît, Gourcerol, Guillaume

المساهمون: Nutrition, Inflammation et axe Microbiote-Intestin-Cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU), Service de Physiologie Digestive, Urinaire, Respiratoire et de l'Exercice CHU Rouen, Hôpital Charles Nicolle Rouen, CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Hôpital Louis Mourier - AP-HP Colombes, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Helios Klinikum Krefeld - Helios Klinikum Krefeld, Universitätsklinikum Tübingen - University Hospital of Tübingen, Eberhard Karls Universität Tübingen = University of Tübingen, Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Centre d'Investigation Clinique CHU Rouen (CIC Rouen), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)

المصدر: ISSN: 1350-1925.

مصطلحات موضوعية: Enterra therapy, chronic vomiting, gastric electrical stimulation, gastroparesis, pregnancy, [SDV]Life Sciences [q-bio]

الوصف: International audience ; Abstract Background Gastric electrical stimulation (GES) is an effective therapy in medically refractory chronic nausea and vomiting. GES is assumed to be a contraindication for pregnancy. We examined the safety of GES during pregnancy and its clinical impact on vomiting symptoms. Methods A retrospective study was performed in two tertiary centers including all female patients of childbearing age implanted with GES. Patients without pregnancy while on GES were asked about their desire and concerns about pregnancy. Patients who were pregnant while on GES therapy were interviewed about the course of the pregnancy and labor, as well as the health of the children. Key Results Among 91 patients implanted at childbearing age, 54 patients without pregnancy answered the questionnaire. Nine patients (16.7%) reported a desire for pregnancy and five patients (7.4%) reported worries about the safety of GES during pregnancy. Sixteen pregnancies were reported in 10 patients. All pregnancies ended in a live birth with premature birth in 12 pregnancies (75.0%). No health concern was currently noted in these children. No severe GES‐related complications occurred during pregnancy with only pain at the implantation site reported during 3 pregnancies (18.8%). The severity and frequency of nausea and vomiting significantly increased during the first trimester ( p = 0.04 and p = 0.005, respectively) and decreased after the delivery, becoming lower than before the pregnancy ( p = 0.044 and p = 0.011, respectively). Conclusion & Inferences Patients are concerned regarding pregnancy while being treated with GES. No serious maternal or fetal complications related to GES were noted in our cohort.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37574861; hal-04206379; https://normandie-univ.hal.science/hal-04206379Test; https://normandie-univ.hal.science/hal-04206379/documentTest; https://normandie-univ.hal.science/hal-04206379/file/Neurogastroenterology%20Motil%20-%202023%20-%20Soliman%20-%20Gastric%20electrical%20stimulation%20is%20safe%20during%20pregnancy%20and%20delivery%20.pdfTest; PUBMED: 37574861

الإتاحة: https://doi.org/10.1111/nmo.14657Test
https://normandie-univ.hal.science/hal-04206379Test
https://normandie-univ.hal.science/hal-04206379/documentTest
https://normandie-univ.hal.science/hal-04206379/file/Neurogastroenterology%20Motil%20-%202023%20-%20Soliman%20-%20Gastric%20electrical%20stimulation%20is%20safe%20during%20pregnancy%20and%20delivery%20.pdfTest

المؤلفون: Daisuke Yakabe, Yusuke Fukuyama, Masahiro Araki, Toshihiro Nakamura

المصدر: Journal of Arrhythmia, Vol 37, Iss 5, Pp 1330-1336 (2021)

مصطلحات موضوعية: atrial fibrillation, catheter ablation, complication, gastroparesis, vagal nerve injury, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Abstract Background Catheter ablation for atrial fibrillation is an effective treatment; however, periesophageal vagal nerve injury is not rare and sometimes results in acute gastroparesis (AGP) after atrial fibrillation ablation (AFA). We sought to investigate the incidence and risk factors of AGP via preprocedural computed tomography (CT) analysis. Methods We retrospectively reviewed 422 patients who underwent index AFA at our center. Using contrast‐enhanced CT performed before ablation, the anatomical characteristics of the esophagus were compared between patients with and without post‐ablation AGP. AGP was diagnosed by the presence of symptoms, fasting abdominal X‐ray radiography as a screening test, and additional abdominal imaging. Results Of the 422 patients (age, 67 ± 11 years; male, 68.5%; cryoballoon, 63.7%), AGP developed in 14 (3.3%) patients, and six of 14 patients were asymptomatic. AGP resolved in all patients within 4 weeks without invasive treatment. In the AGP group, the esophagus was frequently located on the vertebra (middle‐positioned esophagus) (AGP vs non‐AGP, 42.9% vs 11.5%; P = .01), and additional posterior wall ablation was frequently performed (50.0% vs 14.5%; P = .02). In the multivariate analysis, middle‐positioned esophagus (P = .02; odds ratio, 9.0; 95% confidence interval [CI], 1.5‐53.3) and additional posterior wall ablation (P = .01; odds ratio, 7.6; 95% CI, 1.5‐42.1) were independent predictors of AGP. Conclusions Anatomical evaluation of the esophagus using CT may be simple and useful for predicting AGP after AFA. High‐risk patients who have middle‐positioned esophagus or who underwent excessive posterior wall ablation should be followed up closely.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1880-4276Test; https://doaj.org/toc/1883-2148Test

الوصول الحر: https://doaj.org/article/c83268f421204c8aa745da73de73606cTest

المؤلفون: Saad Saleem, Faisal Inayat, Muhammad Aziz, Eric O Then, Yousaf Zafar, Vinaya Gaduputi

المصدر: JGH Open, Vol 5, Iss 3, Pp 350-355 (2021)

مصطلحات موضوعية: gastroparesis, hospitalization, mortality, Diseases of the digestive system. Gastroenterology, RC799-869

الوصف: Abstract Background and Aim To determine the United States‐based in‐hospital gastroparesis mortality rate and independent predictors associated with it. Methods A retrospective study was conducted using the deidentified National Inpatient Sample and Healthcare Cost and Utilization Project database between the years 2012 and 2014. The in‐hospital gastroparesis mortality rate was calculated. Patients' demographics, including age, gender, race, comorbid conditions, and hospital characteristics, were examined as potential predictors of mortality. Results The gastroparesis mortality rate was 3.19 per 1000 gastroparesis patients for the years 2012–2014. Caucasians had the highest mortality rate, with odds ratio (OR) = 2.27; 95% confidence interval (CI) 1.52–3.38, and P = 0.0001. Rural hospitals had higher mortality, with OR = 1.51, 95% CI 1.10–2.10, and P = 0.01, whereas urban nonteaching and teaching hospitals showed no statistically significant mortality difference, with OR = 0.83, 95% CI 0.6–1.15, and P = 0.27 and OR = 0.82, 95% CI 0.59–1.15, and P = 0.25, respectively. In hospitals in the south region, mortality was the highest at 65.6%, with OR = 2.05, 95% CI 1.48–2.84, and P

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2397-9070Test

الوصول الحر: https://doaj.org/article/1837c3e351a44bae8d037b63d8619d6fTest

المؤلفون: Han, Nie, Cheng, Shaodan, Jin, Ye, Li, Guanheng, Wang, Huan, Jin, Lin

المصدر: Neurogastroenterol Motil ; ISSN:1365-2982

مصطلحات موضوعية: ST36, acupoint, diabetic gastroparesis, gastrointestinal motility, low‐intensity pulsed ultrasound

الوصف: Low-intensity pulsed ultrasound (LIPUS) combined with acupoint can promote gastric motility of diabetic rats. The switch of gastric smooth muscle cell (GSMCs) phenotype was related to the diabetes-induced gastric dysfunction, but the mechanism is not clearly elucidated. This study was aimed at exploring the underlying mechanism of LIPUS stimulation application in diabetic gastroparesis rats.

العلاقة: https://doi.org/10.1111/nmo.14843Test; https://pubmed.ncbi.nlm.nih.gov/38873849Test

الإتاحة: https://doi.org/10.1111/nmo.14843Test
https://pubmed.ncbi.nlm.nih.gov/38873849Test

المؤلفون: Varma, Revati, Chakraborty, Subhankar, Burton, Duane D, Bailey, Kent R, Bharucha, Adil E

المصدر: Neurogastroenterol Motil ; ISSN:1365-2982 ; Volume:36 ; Issue:7

مصطلحات موضوعية: abdominal pain, diabetes mellitus, dysbiosis, gastroparesis, neuropathy

الوصف: Although diabetic gastroenteropathy (DGE) is associated with small intestinal bacterial overgrowth (SIBO), most studies have evaluated SIBO with a hydrogen breath test, which may be affected by altered transit in DGE. The risk factors for the consequences of SIBO in DGE are poorly understood. We aimed to evaluate the prevalence of, risk factors for, and gastrointestinal symptoms associated with SIBO in patients with DGE.

العلاقة: https://doi.org/10.1111/nmo.14798Test; https://pubmed.ncbi.nlm.nih.gov/38651669Test

الإتاحة: https://doi.org/10.1111/nmo.14798Test
https://pubmed.ncbi.nlm.nih.gov/38651669Test

المؤلفون: Ashlie Watters, Dennis Gibson, Elizabeth Dee, Margherita Mascolo, Philip S. Mehler

المصدر: Clinical Case Reports, Vol 8, Iss 1, Pp 185-189 (2020)

مصطلحات موضوعية: anorexia nervosa, CT scan, gastroparesis, GI series, superior mesenteric artery syndrome, Medicine, Medicine (General), R5-920

الوصف: Abstract Superior mesenteric artery syndrome presents with nonspecific GI complaints, hindering weight restoration in those with anorexia nervosa. Diagnosis is made with radiologic testing, and treatment requires only weight restoration, negating the need for surgical intervention.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2050-0904Test

الوصول الحر: https://doaj.org/article/f481e98c6e04480a9203e62919a521e0Test

المؤلفون: Nick Goelen, Mike Jones, I‐Hsuan Huang, Florenca Carbone, Pieter Janssen, Jan Tack

المصدر: United European Gastroenterology Journal. 11:146-162

مصطلحات موضوعية: gastroparesis, FEED INTOLERANCE, prokinetic, CLINICAL-TRIAL, DOUBLE-BLIND, INDIGESTIBLE SOLIDS, gastric emptying, cisapride, domperidone, botulinum toxin, REDUCES SYMPTOMS, buspirone, GASTROINTESTINAL SYMPTOMS, DIABETIC GASTROPARESIS, Science & Technology, levosulpiride, Gastroenterology & Hepatology, Gastroenterology, MEAL-RELATED SYMPTOMS, GHRELIN RECEPTOR AGONIST, Oncology, erythromycin, ghrelin, FUNCTIONAL DYSPEPSIA, Life Sciences & Biomedicine, metoclopramide

الوصف: BACKGROUND: Gastroparesis and functional dyspepsia are disorders characterized by upper gastrointestinal symptoms and multifaceted etiologies. One of the main therapeutic approaches is accelerating gastric emptying (GE) by means of prokinetic agents. Their efficacy has been demonstrated, although the association between symptom improvement and acceleration of emptying is less clear. Meta-analyses have found contradictory results. Differences in applied methodology and included trials might drive these contradictions. OBJECTIVE: To provide a transparent meta-analysis update to elucidate the association between symptom improvement and acceleration of GE due to gastroprokinetic agents available for long-term use in patients with gastroparesis. DESIGN: Two approaches from earlier meta-analyses were executed and compared. One analyzed the relative changes on active treatment versus baseline, the other compared the change from baseline on active treatment versus the change from baseline on placebo. Papers that reported sufficient numerical data for both analyses were selected. Both analyses included the same trials. RESULTS: Overall, both approaches yield the same positive direction of association between symptom improvement and acceleration of emptying (0.291 (-0.391, 0.972), p = 0.4 and 0.453 (0.123, 0.782), p = 0.007 for the active-only and placebo-controlled analysis respectively). The association between symptom improvement and GE acceleration for studies using optimal GE tests was either 0.028 (p > 0.9) or 0.463 (p = 0.007), and for sub-optimal GE tests was either 0.370 (p = 0.4) or 0.052 (p > 0.9) depending on the used meta-analysis methodology. CONCLUSIONS: The applied methodology for GE testing, and the meta-analysis substantially impacts the conclusion. When considering the clinically relevant outcome of improvement from baseline, symptoms and emptying improve with prokinetics, but no correlation is found between both aspects. When the change over placebo is considered, limiting the analysis to scientifically more rigorous study approaches, changes in emptying rate and symptom improvement are positively associated. ispartof: UNITED EUROPEAN GASTROENTEROLOGY JOURNAL vol:11 issue:2 ispartof: location:England status: Published online

وصف الملف: Print-Electronic

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86d3f96b9ad55e5cc87f8d5bbd0a893cTest
https://doi.org/10.1002/ueg2.12362Test

المؤلفون: Henry P. Parkman

المصدر: Textbook of Gastroenterology

مصطلحات موضوعية: medicine.medical_specialty, Gastric emptying, business.industry, Diabetic gastroparesis, Gastric motility, Erythromycin, medicine.disease, Gastroenterology, Stomach emptying, Internal medicine, medicine, Dumping syndrome, Gastroparesis, business, Antrum, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cac815e449f9ff2fe242468985a531cTest
https://doi.org/10.1002/9781119600527.ch15Test