The antitumor effect of hinesol, extract from Atractylodes lancea ( Thunb. ) DC. by proliferation, inhibition, and apoptosis induction via MEK/ERK and NF‐κB pathway in non–small cell lung cancer cell lines A549 and NCI‐H1299
| العنوان: | The antitumor effect of hinesol, extract from Atractylodes lancea ( Thunb. ) DC. by proliferation, inhibition, and apoptosis induction via MEK/ERK and NF‐κB pathway in non–small cell lung cancer cell lines A549 and NCI‐H1299 |
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| المؤلفون: | Xin Ju, Bin Xu, Hongxia Yuan, Liangzhi Li, Jia-Hui Du, Songbai Liu, Fenju Qin, Weiqiang Guo |
| المصدر: | Journal of Cellular Biochemistry. 120:18600-18607 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, A549 cell, MAPK/ERK pathway, Cell cycle checkpoint, biology, Kinase, Chemistry, Cell Biology, biology.organism_classification, Biochemistry, respiratory tract diseases, 03 medical and health sciences, IκBα, 030104 developmental biology, 0302 clinical medicine, Apoptosis, 030220 oncology & carcinogenesis, Cancer research, Atractylodes lancea, Protein kinase A, Molecular Biology |
| الوصف: | Lung cancer (especially, non-small cell lung cancer [NSCLC]) is one of the most malignant cancers in the world. Hinesol is the major component of the essential oil of Atractylodes lancea (Thunb.) DC and possesses the most promising anticancer function. However, the effects and molecular mechanism of hinesol on antiproliferation in NSCLC cells has not been well understood. In this study, we found that hinesol effectively inhibited the A549 and NCI-H1299 cells in a dose- and time-dependent manner by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide assay. In addition, hinesol induced cell cycle arrest at G0/G1 phase and apoptosis assessed by flow cytometry in A549 cells. Furthermore, Western blot analysis showed that hinesol decreased phosphorylation of mitogen-activated protein kinase, extracellular signal-regulated kinase, IκBα, and p65 inhibited the expressions of Bcl-2, cyclin D1 and upregulated the expression of Bax. Based on these results, hinesol might be a potential drug candidate of anti-NSCLC for therapy. |
| تدمد: | 1097-4644 0730-2312 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::124c5394fedce02beb2e2b2514d0d103Test https://doi.org/10.1002/jcb.28696Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........124c5394fedce02beb2e2b2514d0d103 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10974644 07302312 |
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