التفاصيل البيبلوغرافية
| العنوان: |
Insulin resistance: Review of the underlying molecular mechanisms |
| المؤلفون: |
Yaribeygi, Habib, Farrokhi, Farin Rashid, Butler, Alexandra E., Sahebkar, Amirhossein |
| المصدر: |
Journal of Cellular Physiology ; volume 234, issue 6, page 8152-8161 ; ISSN 0021-9541 1097-4652 |
| بيانات النشر: |
Wiley |
| سنة النشر: |
2018 |
| المجموعة: |
Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: |
Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin. Insulin signaling is therefore critical for these tissues. However, decrease in insulin sensitivity due to the disruption of various molecular pathways causes insulin resistance (IR). IR underpins many metabolic disorders such as type 2 diabetes and metabolic syndrome, impairments in insulin signaling disrupting entry of glucose into the adipocytes, and skeletal muscle cells. Although the exact underlying cause of IR has not been fully elucidated, a number of major mechanisms, including oxidative stress, inflammation, insulin receptor mutations, endoplasmic reticulum stress, and mitochondrial dysfunction have been suggested. In this review, we consider the role these cellular mechanisms play in the development of IR. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1002/jcp.27603 |
| الإتاحة: |
https://doi.org/10.1002/jcp.27603Test |
| حقوق: |
http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: |
edsbas.D3CD50B3 |
| قاعدة البيانات: |
BASE |
