دورية أكاديمية

Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib

التفاصيل البيبلوغرافية
العنوان: Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib
المؤلفون: Narayan Shivapurkar, Eveline E. Vietsch, Erin Carney, Claudine Isaacs, Anton Wellstein
المصدر: Clinical and Translational Medicine, Vol 6, Iss 1, Pp 1-10 (2017)
بيانات النشر: Wiley, 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine (General)
مصطلحات موضوعية: MicroRNA, Liquid biopsy, Tyrosine kinase inhibitor, Breast cancer, Clinical trial, Medicine (General), R5-920
الوصف: Abstract Background Serial analysis of biomarkers in the circulation of patients undergoing treatment (“liquid biopsies”) can provide new insights into drug effects. In particular the analysis of cell-free, circulating nucleic acids such as microRNAs (miRs) can reveal altered expression patterns indicative of mechanism of drug action, cancer growth, and tumor–stroma interactions. Results Here we analyzed plasma miRs in patients with hormone receptor positive, metastatic breast cancer with prior disease progression during aromatase inhibitor therapy (n = 8) in a phase I/II trial with the multiple tyrosine kinase inhibitor dovitinib (TKI258). Plasma miR levels were measured by quantitative RT-qPCR before and after treatment with dovitinib. A candidate miR signature of drug response was established from a 379 miR screen for detectable plasma miRs as well as from the published literature. Changes in miR expression patterns and tumor sizes were compared. In this analysis we identified miR-21-5p, miR-100-5p, miR-125b-5p, miR-126-3p, miR-375 and miR-424-5p as potential indicators of a response to dovitinib. The altered expression patterns observed for the six circulating miRs separated patients with resistant disease from those with drug responsive disease. There was no relationship between adverse effects of dovitinib treatment and identifiable changes in miR patterns. Conclusion We conclude that changes in the expression patterns of circulating miRs can be indicators of drug responses that merit prospective studies for validation.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2001-1326
العلاقة: http://link.springer.com/article/10.1186/s40169-017-0169-yTest; https://doaj.org/toc/2001-1326Test
DOI: 10.1186/s40169-017-0169-y
الوصول الحر: https://doaj.org/article/4e8fe86b0417486c92c79869cb949453Test
رقم الانضمام: edsdoj.4e8fe86b0417486c92c79869cb949453
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20011326
DOI:10.1186/s40169-017-0169-y