دورية أكاديمية
Survival in multiple myeloma and SARS-COV-2 infection through the COVID-19 pandemic: Results from the EPICOVIDEHA registry
| العنوان: | Survival in multiple myeloma and SARS-COV-2 infection through the COVID-19 pandemic: Results from the EPICOVIDEHA registry |
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| المؤلفون: | Musto, Pellegrino, Sgherza, Nicola, Bergantim, Rui, Farina, Francesca, Glenthøj, Andreas, Salmanton-García, Jon, Jiménez, Moraima |
| المساهمون: | Institut Català de la Salut, Musto P Department of Precision and Regenerative Medicine and Ionian Area, "Aldo Moro" University School of Medicine, Bari, Italy. Hematology and Stem Cell Transplantation Unit, AOUC Policlinico, Bari, Italy. Salmanton‐García J University of Cologne, Faculty of Medicine and University Hospital Cologne, Institute of Translational Research, Cologne Excellence Cluster on Cellular Stress Responses in Aging‐Associated Diseases (CECAD), Cologne, Germany. Department I of Internal Medicine, University of Cologne, Faculty of Medicine and University Hospital Cologne, Excellence Center for Medical Mycology (ECMM), Cologne, Germany. German Centre for Infection Research (DZIF), Partner Site Bonn‐Cologne, Cologne, Germany. Sgherza N Hematology and Stem Cell Transplantation Unit, AOUC Policlinico, Bari, Italy. Bergantim R Centro Hospitalar e Universitário São João, Porto, Portugal. Farina F IRCCS Ospedale San Raffaele, Milan, Italy. Glenthøj A Department of Hematology, Copenhagen University Hospital ‐ Rigshospitalet, Copenhagen, Denmark. Jiménez M Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus |
| المصدر: | Scientia |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | COVID-19 (Malaltia), Mieloma múltiple, DISEASES::Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections, DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Plasma Cell::Multiple Myeloma, ENFERMEDADES::virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus, ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de células plasmáticas::mieloma múltiple |
| الوصف: | COVID-19; SARS-CoV-2; Multiple myeloma ; COVID-19; SARS-CoV-2; Mieloma múltiple ; COVID-19; SARS-CoV-2; Mieloma múltiple ; Patients affected by multiple myeloma (MM) have an increased risk of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and subsequent coronavirus (20)19 disease (COVID-19)-related death. The changing epidemiological and therapeutic scenarios suggest that there has been an improvement in severity and survival of COVID-19 during the different waves of the pandemic in the general population, but this has not been investigated yet in MM patients. Here we analyzed a large cohort of 1221 patients with MM and confirmed SARS-CoV-2 infection observed between February 2020, and August 2022, in the EPICOVIDEHA registry from 132 centers around the world. Median follow-up was 52 days for the entire cohort and 83 days for survivors. Three-hundred and three patients died (24%) and COVID-19 was the primary reason for death of around 89% of them. Overall survival (OS) was significantly higher in vaccinated patients with both stable and active MM versus unvaccinated, while only a trend favoring vaccinated patients was observed in subjects with responsive MM. Vaccinated patients with at least 2 doses showed a better OS than those with one or no vaccine dose. Overall, according to pandemic waves, mortality rate decreased over time from 34% to 10%. In multivariable analysis, age, renal failure, active disease, hospital, and intensive care unit admission, were independently associated with a higher number of deaths, while a neutrophil count above 0.5 × 109/L was found to be protective. This data suggests that MM patients remain at risk of SARS-CoV-2 infection even in the vaccination era, but their clinical outcome, in terms of OS, has progressively improved throughout the different viral phases of the pandemic. ; EPICOVIDEHA has received funds from Optics COMMIT (COVID-19 Unmet Medical Needs and Associated Research Extension) COVID-19 RFP program by GILEAD Science, United States (Project ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0278-0232 |
| العلاقة: | Hematological Oncology;42(1); https://doi.org/10.1002/hon.3240Test; Musto P, Salmanton-García J, Sgherza N, Bergantim R, Farina F, Glenthøj A, et al. Survival in multiple myeloma and SARS-COV-2 infection through the COVID-19 pandemic: Results from the epicovideha registry. Hematol Oncol. 2024 Jan;42(1):e3240.; https://hdl.handle.net/11351/10952Test; 001119708300001 |
| DOI: | 10.1002/hon.3240 |
| الإتاحة: | https://doi.org/10.1002/hon.3240Test https://hdl.handle.net/11351/10952Test |
| حقوق: | Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0Test/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.117879BF |
| قاعدة البيانات: | BASE |
| تدمد: | 02780232 |
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| DOI: | 10.1002/hon.3240 |