المؤلفون: Masashi Kanai, Takahisa Kawaguchi, Masahito Kotaka, Dai Manaka, Junichi Hasegawa, Akinori Takagane, Yoshinori Munemoto, Takeshi Kato, Tetsuya Eto, Tetsuo Touyama, Takanori Matsui, Katsunori Shinozaki, Shigemi Matsumoto, Tsunekazu Mizushima, Masaki Mori, Junichi Sakamoto, Atsushi Ohtsu, Takayuki Yoshino, Shigetoyo Saji, Fumihiko Matsuda

المصدر: Cancer Medicine, Vol 12, Iss 7, Pp 7808-7814 (2023)

مصطلحات موضوعية: Asian population, DPYD, fluoropyrimidine, genotyping, toxicity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-7634Test

الوصول الحر: https://doaj.org/article/22d0decfa3754b00b4a85b0440d3496aTest

المؤلفون: Lennard Y. W. Lee, Thomas Starkey, Shivan Sivakumar, Susan Fotheringham, Guy Mozolowski, Vanessa Shearwood, Claire Palles, Philip Camilleri, David Church, Rachel Kerr, David Kerr

المصدر: Cancer Medicine, Vol 8, Iss 14, Pp 6305-6314 (2019)

مصطلحات موضوعية: chemotherapy, Colorectal cancer, DPYD, ENOSF1, fluoropyrimidine, genetic testing, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2045-7634Test

الوصول الحر: https://doaj.org/article/63331bd09b3348e393f3e083b2d7ea93Test

المؤلفون: Deying Liu, Tian Luo, Zhisheng Liu, Yi Wang, Chunhui Hu

المصدر: Epileptic Disorders. 24:343-352

مصطلحات موضوعية: Brain Diseases, Valproic Acid, Mutation, DNA Copy Number Variations, business.industry, Encephalopathy, Infant, General Medicine, Gene mutation, Bioinformatics, medicine.disease_cause, medicine.disease, Phenotype, Neurology, Genetic variation, Humans, Medicine, STXBP1, DPYD, Neurology (clinical), Copy-number variation, business, Spasms, Infantile, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df118745a35bf1567e2322a2c8c2c0baTest
https://doi.org/10.1684/epd.2021.1394Test

المؤلفون: Kelly Williams, Brittney H. Davis, Nita A. Limdi, Devin Absher, Bruce R. Korf

المصدر: Clinical and Translational Science, Vol 14, Iss 6, Pp 2327-2338 (2021)
Clinical and Translational Science

مصطلحات موضوعية: Adult, Male, CYP2D6, Prescription Drugs, Adolescent, Genotype, Genetic genealogy, MEDLINE, CYP2C19, RM1-950, Article, General Biochemistry, Genetics and Molecular Biology, Young Adult, Pharmacotherapy, Humans, Medicine, Precision Medicine, General Pharmacology, Toxicology and Pharmaceutics, business.industry, Research, General Neuroscience, Articles, General Medicine, Middle Aged, Pharmacogenomic Testing, Cytochrome P-450 CYP2C19, Genetics, Population, Cytochrome P-450 CYP2D6, Pharmacogenetics, Alabama, Female, DPYD, Therapeutics. Pharmacology, Public aspects of medicine, RA1-1270, business, Demography

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca81bdca6195ef4999b7124f603534b9Test
https://doaj.org/article/d2f206528b0f46e5aa0f3e0e2001aa3fTest

المؤلفون: Yun-Hee Choi, Wendy A. Teft, Theodore J. Wigle, Veera Durga Sravanthi Panuganty, Samantha Medwid, Richard B. Kim, Sisira Sarma, Brandi L. Povitz, Victoria Siebring, Ute I. Schwarz, Denise Keller, Jaymie Mailloux, John Lenehan, Robin M. Legan, Stephanie Nevison, Eric Winquist, Stephen Welch

المصدر: Clinical and Translational Science, Vol 14, Iss 4, Pp 1338-1348 (2021)
Paediatrics Publications
Clinical and Translational Science

مصطلحات موضوعية: Male, Antimetabolites, Antineoplastic, Canada, Heterozygote, 030213 general clinical medicine, medicine.medical_specialty, Dihydropyrimidine Dehydrogenase Deficiency, Pharmacogenomic Variants, Context (language use), RM1-950, Medical Oncology, 030226 pharmacology & pharmacy, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, Internal medicine, medicine, Dihydropyrimidine dehydrogenase, Humans, Dosing, Precision Medicine, General Pharmacology, Toxicology and Pharmaceutics, Adverse effect, Capecitabine, Dihydrouracil Dehydrogenase (NADP), Aged, Retrospective Studies, business.industry, Research, General Neuroscience, Common Terminology Criteria for Adverse Events, Articles, General Medicine, Middle Aged, Pharmacogenomic Testing, Discontinuation, Practice Guidelines as Topic, Female, DPYD, Fluorouracil, Therapeutics. Pharmacology, Public aspects of medicine, RA1-1270, business, Pharmacogenetics

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3004363d45b2bbe7858526db3654ea78Test
https://doaj.org/article/cb2d4022d64843098a58cd559aa1c31bTest

المؤلفون: Helsby, Nuala A, Duley, John, Burns, Kathryn E, Bonnet, Claire, Jeong, Soo Hee, Brenman, Elliott, Barlow, Paula, Sharples, Katrina, Porter, David, Findlay, Michael

مصطلحات موضوعية: Humans, Fluorouracil, Thymine, Dihydrouracil Dehydrogenase (NADP), Diagnostic Tests, Routine, Case-Control Studies, Capecitabine, anticancer drugs, biomarkers, clinical pharmacology, genetics and pharmacogenetics, medication safety, oncology, Clinical Research, Kidney Disease, Science & Technology, Life Sciences & Biomedicine, Pharmacology & Pharmacy, 5-FLUOROURACIL TOXICITY, CLINICAL-RELEVANCE, DPYD VARIANTS, DPD ACTIVITY, PHARMACOKINETICS, METABOLITES, CLEARANCE, REGIMENS, EFFICACY, 1103 Clinical Sciences, Clinical

جغرافية الموضوع: England

وصف الملف: Print-Electronic; application/pdf

العلاقة: British journal of clinical pharmacology; (2020). British Journal of Clinical Pharmacology, 86(1), 155-164.; https://hdl.handle.net/2292/62379Test; 31658382 (pubmed)

الإتاحة: https://doi.org/10.1111/bcp.14153Test
https://hdl.handle.net/2292/62379Test

المؤلفون: Koobmeej Lee, Heather Zierhut, Katherine Holzer, Kathleen A. Culhane-Pera, Txia Xiong, Robert J. Straka, Bharat Thyagarajan, Jeffrey R. Bishop, Muaj Lo, Ya Feng Wen, Kerui Peng

المصدر: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 40:142-152

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, China, Adolescent, CYP4F2, 030106 microbiology, CYP2C19, 030204 cardiovascular system & hematology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Asian People, Gene Frequency, Humans, Medicine, Pharmacology (medical), Clinical significance, Allele frequency, Aged, Cytochrome P-450 CYP2C9, Aged, 80 and over, biology, business.industry, Anticoagulants, Middle Aged, United States, Pharmacogenetics, biology.protein, Female, DPYD, Warfarin, VKORC1, SLCO1B1, business, Demography

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05da352ba9ca84c2f0b62f1a024b5db6Test
https://doi.org/10.1002/phar.2360Test

المؤلفون: Paula Barlow, Elliott Brenman, Michael Findlay, Kathryn E Burns, Soo Hee Jeong, John A. Duley, Katrina Sharples, David Porter, Nuala A. Helsby, Claire Bonnet

المصدر: Br J Clin Pharmacol

مصطلحات موضوعية: medicine.medical_specialty, Urinary system, Renal function, 030226 pharmacology & pharmacy, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Internal medicine, medicine, Humans, Pharmacology (medical), 030212 general & internal medicine, Capecitabine, Dihydrouracil Dehydrogenase (NADP), Pharmacology, Diagnostic Tests, Routine, business.industry, Case-control study, Common Terminology Criteria for Adverse Events, Original Articles, Confidence interval, Case-Control Studies, Toxicity, DPYD, Fluorouracil, business, Thymine

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::360e81cd43516518e988a2fe810d17b4Test
https://doi.org/10.1111/bcp.14153Test

المؤلفون: Didier Meulendijks, Anthonius de Boer, Lisanne N. van Merendonk, Annemieke Cats, Jan H.M. Schellens, Jos H. Beijnen, Maarten J. Deenen, Linda M. Henricks

المصدر: International Journal of Cancer. 144:2347-2354

مصطلحات موضوعية: Oncology, Cancer Research, medicine.medical_specialty, Chemotherapy, business.industry, medicine.medical_treatment, medicine.disease, Capecitabine, 03 medical and health sciences, Dihydropyrimidine dehydrogenase deficiency, 0302 clinical medicine, 030220 oncology & carcinogenesis, Internal medicine, Toxicity, Cohort, medicine, Dihydropyrimidine dehydrogenase, DPYD, Dosing, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3cb053e49840a0df38219f7020d1844aTest
https://doi.org/10.1002/ijc.32022Test

المؤلفون: Ling Fang, Shan-Shan Zhuang, Guodong Qiu, Chen Chen, Yun-Sheng Qin, She Yuqi, Zheng Jieting, Kai Lin, Hong Jiang, Shuyao Zhang

المصدر: The FASEB Journal. 33:1972-1988

مصطلحات موضوعية: Male, 0301 basic medicine, Esophageal Neoplasms, Mice, Nude, Biology, Biochemistry, DNA methyltransferase, Mice, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Genetics, Dihydropyrimidine dehydrogenase, medicine, Animals, Humans, Gene silencing, RNA, Neoplasm, Promoter Regions, Genetic, Molecular Biology, Dihydrouracil Dehydrogenase (NADP), Mice, Inbred BALB C, DNA, Neoplasm, Methylation, DNA Methylation, Esophageal cancer, medicine.disease, Xenograft Model Antitumor Assays, Neoplasm Proteins, 030104 developmental biology, Drug Resistance, Neoplasm, Apoptosis, DNA methylation, Cancer research, Female, RNA, Long Noncoding, DPYD, Fluorouracil, 030217 neurology & neurosurgery, Biotechnology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f790c550dd11faf6d93dab67dc2d66Test
https://doi.org/10.1096/fj.201800759rTest